Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Knosp grade 4 adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is a rare cause of Cushing disease. 30431585 2018
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE We characterized SCAs based on clinical, hormonal and molecular data, and compared the characteristics of these tumours with those of macro (MCA)- and micro (mCA)-ACTH adenomas with Cushing's disease. 20385723 2010
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Cushing disease (CD) is a rare entity caused by ACTH-secreting pituitary tumours, leading to prolonged hypercortisolism. 29927501 2018
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE OBJECT Functional corticotroph pituitary adenomas (PAs) secrete adrenocorticotropic hormone (ACTH) and are the cause of Cushing's disease, which accounts for 70% of all cases of Cushing's syndrome. 25639319 2015
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE The primary treatment of Cushing disease (hypercortisolism due to ACTH-producing adenomas, which is the cause in approximately 65% of the cases of hypercortisolism) is adenoma resection and medical therapies including ketoconazole, mifepristone, and pasireotide. 28170483 2017
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Age of patients ranged from 52 to 72, five females and one male, four with Cushing's disease and two with ectopic ACTH production, one from a pancreatic neuroendocrine tumor and one from medullary carcinoma of the thyroid. 31001560 2019
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Cushing disease (CD) due to adrenocorticotropic hormone-secreting pituitary tumors can be a management challenge. 28938462 2017
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE We present an unusual case of Turner syndrome (TS) and Cushing disease (CD) in a young woman, admitted to our department seven years after a successful surgical removal of ACTH-secreting pituitary tumor. 31242778 2019
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Coexisting pituicytoma and adrenocorticotropic hormone adenoma were identified in one patient with a diagnosis of Cushing disease. 29749277 2018
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE These results indicate that subtype 1 silent adenomas and clinically active adenomas associated with Cushing's disease contain POMC mRNA that is readily detectable by ISH in routinely processed tissue specimens, while only a few of the subtypes 2 and 3 adenomas have POMC mRNA that can be detected in paraffin blocks with the oligonucleotide probes used in this study. 2167013 1990
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Microadenomas that strongly express POMC were common among mutated tumors, which may lead to the mechanisms by which very small adenomas secrete excess ACTH to present overt CD. 26578638 2016
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Investigations suggested Cushing's disease; there was suppression after high-dose dexamethasone (<20 nmol/liter) and a 950% increase in ACTH after stimulation with CRH. 11788623 2002
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH-secreting pulmonary carcinoids, like the corticotroph adenomas causing Cushing's disease, are often small and difficult to detect, and patients present with a gradual onset of the classical signs and symptoms of Cushing's syndrome, indistinguishable from the presentation of Cushing's disease. 29754641 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Thirteen consecutive patients were diagnosed with Cushing's disease using uncorrected ACTH ratios. 28626863 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-dependent Cushing's syndrome; they were, however, also increased in some patients with non-GIP-dependent cortisol-secreting adenomas or with ACTH-dependent Cushing's disease. 16087722 2005
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is the result of excess secretion of adrenocorticotropic hormone (ACTH) by a benign monoclonal pituitary adenoma. 27104844 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE NEPVs for cortisol and ACTH predicted nonremission after TSS for CD. 28323961 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) arises from pituitary-dependent glucocorticoid excess due to an ACTH-secreting corticotroph tumor. 26012588 2015
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE RNA was extracted from adrenal tissues from nine patients with GIP-dependent CS [seven ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH), two adenomas], two control whole adult adrenals, two fasciculata cell-enriched preparations from normal adrenals, seven patients with Cushing's disease (CD) and two normal pancreas. 16402925 2006
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Adrenocorticotropic hormone (ACTH)-secreting adenomas account for Cushing's disease (CD) which is the most common form of ACTH-dependent Cushing's syndrome (CS). 30488233 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE An early post-operative ACTH suppression test can safely predict short- and long-term remission after surgery of Cushing's disease. 30039432 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Pituitary magnetic resonance imaging (MRI) revealed a 3.5 mm microadenoma and inferior petrosal sinus sampling of adrenocorticotropic hormone (ACTH) after corticotropin releasing hormone (CRH) stimulation confirmed ACTH-dependent CD. 31251726 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone-secreting pituitary tumor. 28614003 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is caused by a corticotroph adenoma of the pituitary gland that secretes excess adrenocorticotropic hormone (ACTH) causing increased morbidity and mortality. 27894193 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Next to the traditional tests, a cutoff of preoperative ACTH/cortisol ratio, an ultrasensitive late night salivary cortisol assay and the desmopressin test have been suggested as valid tools for the diagnosis and differential diagnosis of CD. 30130808 2019