|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The pathophysiological mechanism of pituitary ACTH oversecretion in Cushing's disease remains unclear.
|
1322426 |
1992 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unrestrained production of proopiomelanocortin (POMC) and its peptide fragments by pituitary corticotroph adenomas in Cushing's disease.
|
1327071 |
1992 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analysis revealed that the size of pro-opiomelanocortin mRNA present in the SCCA tissue was indistinguishable from that in the adenomas associated with Cushing's disease.
|
2153197 |
1990 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that subtype 1 silent adenomas and clinically active adenomas associated with Cushing's disease contain POMC mRNA that is readily detectable by ISH in routinely processed tissue specimens, while only a few of the subtypes 2 and 3 adenomas have POMC mRNA that can be detected in paraffin blocks with the oligonucleotide probes used in this study.
|
2167013 |
1990 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
No PC2 messenger ribonucleic acid could be detected in the small cell carcinoma of the lung-derived DMS-79 human cell line, which produces unprocessed POMC, or in three pituitary tumors responsible for Cushing's disease or Nelson's syndrome, which produced intact ACTH, but no CLIP.
|
7962350 |
1994 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transition from Cushing's disease to ACTH-independence is not supported by the available data.
|
8038906 |
1994 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nelson's syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing's disease.
|
8550738 |
1996 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We speculate that the response to the desmopressin test observed in patients with Cushing's disease may be due to abnormal expression of V3R or V2R in ACTH-secreting tumors.
|
8626831 |
1996 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This case illustrates that ACTH stimulation by desmopressin is not specific for pituitary-dependent Cushing's syndrome as vasopressin receptor subtypes known to interact with desmopressin may also be found in ectopic tumours producing ACTH.
|
9425403 |
1997 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently it was shown that patients with pituitary corticotrope adenomas respond to GHS with a dramatic rise in ACTH secretion, and it has been suggested that GHS may provide a diagnostic tool to differentiate Cushing's disease from the ectopic ACTH syndrome.
|
9437242 |
1997 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the DDAVP stimulation test, i.e., determination of plasma ACTH levels after 5 microg DDAVP injection, seems useful for discriminating Cushing's disease from normality, and may serve to facilitate the differentiation between Cushing's disease and ectopic ACTH syndrome.
|
9466324 |
1997 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hypertension is a prominent feature of patients with Cushing's disease and ectopic adrenocorticotropic hormone (ACTH) syndrome, who have elevated ACTH levels.
|
11082157 |
2000 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in vivo Bcl-2 protein analysis showed its down-regulation in adrenal hyperplasia of Cushing's disease despite ACTH stimulation.
|
11196462 |
2000 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Investigations suggested Cushing's disease; there was suppression after high-dose dexamethasone (<20 nmol/liter) and a 950% increase in ACTH after stimulation with CRH.
|
11788623 |
2002 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Following desmopressin administration there was an overlap of the percent F and ACTH responses among patients with CD and EAS, and the area under the ROC curve for both these responses was not significantly different than that occurring by chance.
|
11932296 |
2002 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, cultures taken from all four ACTH-dependent and the one food-dependent hyperplastic adrenals studied were also responsive to GIP (EC50 for cAMP, 1.3 x 10(-9) M in Cushing's disease and 4.1 x 10(-10) M in food-dependent disease).
|
15705925 |
2005 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The selective expression of sst(5) receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing's disease.
|
15817922 |
2005 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-dependent Cushing's syndrome; they were, however, also increased in some patients with non-GIP-dependent cortisol-secreting adenomas or with ACTH-dependent Cushing's disease.
|
16087722 |
2005 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
RNA was extracted from adrenal tissues from nine patients with GIP-dependent CS [seven ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH), two adenomas], two control whole adult adrenals, two fasciculata cell-enriched preparations from normal adrenals, seven patients with Cushing's disease (CD) and two normal pancreas.
|
16402925 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings provide a plausible cellular basis for the exaggerated ACTH response to ghrelin in Cushing's disease and suggest novel research strategies to develop medical treatments for this disease.
|
16551736 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic adrenal stimulation by ACTH in Cushing's disease or GIP in GIP-dependent ACTH-independent macronodular adrenal hyperplasia both lead to the induction of genes implicated in adrenal proliferation and steroidogenesis.
|
16772347 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Cushing disease, which is caused by the excessive production of ACTH, is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment.
|
16809932 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.
|
17043312 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.
|
17043312 |
2006 |
|
Pituitary-dependent Cushing's disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GH secretagogues (GHS) have been used for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS) since 1997 due to their ability to increase ACTH and cortisol levels in Cushing's disease.
|
17556872 |
2007 |