POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Alpha melanocyte stimulating hormone (α-MSH) enhances melanogenesis in melanoma malignum by binding to melanocortin-1 receptors (MC1-R). 28625749 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE This may be a reason for concern in patients with malignant melanoma (MM): Melanocortin receptors bind to ACTH and the different isoforms of MSH. 31272482 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Furthermore, the relevance of alpha-melanocyte-stimulating hormone-mediated signaling for the induction of cytotoxicity was assessed in CD8(+) T cells from melanoma patients with functional and nonfunctional melanocortin-1 receptors. 20126537 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human Because the apoptotic cells were detected mainly in regions distant from blood vessels, it was hypothesized that POMC therapy might render melanoma cells vulnerable to hypoxic insult. 24412703 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease LHGDN In CRH positive melanomas, seven out of nine cases (78%) of primary melanoma, and 7 out of 12 cases (58%) of MetM showed colocalization of CRH and POMC peptides. 11936276 2002