The role of Oxycontin was analyzed by collecting the patients' general information, age, gender, Karnofsky performance status (KPS) score, site of pain and degree of pain, and by detecting the remission rates of clinical symptoms, average analgesic time, number of pain outbreak per day, levels of β-EP, CGRP and PGE2, as well as changes of KPS score, Zubrod performance status (ZPS) score and quality of life (QoL) score of the enrolled patients before treatment and at 1 week afer treatment.
In this study, we report that α-MSH suppresses the transient outward A-type K<sup>+</sup> current (<i>I</i><sub>A</sub>) in trigeminal ganglion (TG) neurons and thereby modulates neuronal excitability and peripheral pain sensitivity in rats.
This study investigated the effects of intracerebroventricular (ICV) and intra-arcuate nucleus (ARC) injection of ghrelin on pain behavioral responses and levels of β-endorphin (β-EP) and met-enkephalin (MENK) in the periaqueductal gray area (PAG) during the formalin test in rats.
Regression analyses indicated that β-endorphin level was negatively related to pressure pain threshold (β = -17.18, <i>p</i> = .02) and positively related to punctate mechanical pain (β = 17.13, <i>p</i> = .04), after controlling for age, gender, and OA severity.