Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Previously, we demonstrated that characteristic age-related shifts in the catabolic effects of α-MSH may contribute both to middle-aged obesity and aging anorexia.
|
29099963 |
2018 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Mice with POMC neuron-specific Sel1L deficiency developed age-associated obesity due, at least in part, to the ER retention of POMC that led to hyperphagia.
|
29457782 |
2018 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity.
|
29168299 |
2018 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and α-MSH) neuropeptides levels among obese adolescents submitted to 1year of multicomponent weight loss therapy.
|
28801068 |
2017 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH).
|
28324042 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Although the primary cause of obesity is unknown, there is significant effort to understand the role of the central melanocortin pathway in the brain as it has been shown that deficiency of proopiomelanocortin (POMC) [10,11] and melanocortin 4 receptors (MC4R) [12-15] in both rodents and humans results in severe hyperphagia and obesity [16-23].
|
28499988 |
2017 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases sympathetic nerve activity (SNA) via activation of proopiomelanocortin neurons in the arcuate nucleus (ArcN), and this action requires simultaneous withdrawal of tonic neuropeptide Y (NPY) sympathoinhibition.
|
28628036 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Together, this work not only identifies a beneficial role for ATF4 in hypothalamic POMC neurons in the regulation of obesity, but also provides a new potential therapeutic target for obesity and obesity-related metabolic diseases.
|
28350524 |
2017 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity.
|
28771698 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
POMC deficiency results in significant morbidity due to obesity, and it is also a potentially life threatening disease because of adrenal insufficiency.
|
28915118 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, we provide the first direct evidence for a diet-dependent deterioration of Ca<sup>2+</sup> homeostasis in POMC neurons during obesity development resulting in impaired function of these critical energy homeostasis-regulating neurons.
|
28762947 |
2017 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of mIL-10 using AAV vector ameliorated obesity in parallel with restoration of ARC POMC expression in DIO mice.
|
27939689 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study demonstrated a great role of αMSH in adipocyte apoptosis and brings a new therapeutic mean to the treatment of obesity and diabetes.
|
28388573 |
2017 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension.
|
28274841 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc<sup>-/-</sup>) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance.
|
29031726 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Similarly, selective deletion of the aPKC isoform <i>Pkc-λ</i> in proopiomelanocortin (POMC) neurons disrupts leptin action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin resistance specifically in HFD-fed male mice.
|
28073831 |
2017 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH)-secreting tumors account for 2% to 6% of adenomas and are associated with obesity, hypertension, diabetes, and other morbidity.
|
28170483 |
2017 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Serum copeptin was significantly associated with HPA responsiveness in OB (post-CRH ACTH: R=0.42, P<0.01), driven by OB men (post-CRH ACTH: R=0.76, P<0.01, post-CRH cortisol: R=0.64, P=0.02).
|
28167369 |
2017 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin.
|
27468060 |
2016 |
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity.
|
27623943 |
2016 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
INPP5E, SNX17, ERAP2, FN3KRP), and obesity (e.g.POMC, CPEB4).
|
27193597 |
2016 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The best interaction model for predicting obesity risk by MDR analysis was the three factor model including POMC (C > T), MC4R (T > C) and APOE (Hha1) polymorphisms.
|
26226973 |
2016 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity.
|
24890885 |
2015 |
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity.
|
26103132 |
2015 |
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Therefore, these common variants in PCSK1 and POMC were not the major cause of obesity in the Thai subjects sampled.
|
26345846 |
2015 |