POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Previously, we demonstrated that characteristic age-related shifts in the catabolic effects of α-MSH may contribute both to middle-aged obesity and aging anorexia. 29099963 2018
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Mice with POMC neuron-specific Sel1L deficiency developed age-associated obesity due, at least in part, to the ER retention of POMC that led to hyperphagia. 29457782 2018
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. 29168299 2018
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and α-MSH) neuropeptides levels among obese adolescents submitted to 1year of multicomponent weight loss therapy. 28801068 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH). 28324042 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Although the primary cause of obesity is unknown, there is significant effort to understand the role of the central melanocortin pathway in the brain as it has been shown that deficiency of proopiomelanocortin (POMC) [10,11] and melanocortin 4 receptors (MC4R) [12-15] in both rodents and humans results in severe hyperphagia and obesity [16-23]. 28499988 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE Obesity increases sympathetic nerve activity (SNA) via activation of proopiomelanocortin neurons in the arcuate nucleus (ArcN), and this action requires simultaneous withdrawal of tonic neuropeptide Y (NPY) sympathoinhibition. 28628036 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Together, this work not only identifies a beneficial role for ATF4 in hypothalamic POMC neurons in the regulation of obesity, but also provides a new potential therapeutic target for obesity and obesity-related metabolic diseases. 28350524 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity. 28771698 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE POMC deficiency results in significant morbidity due to obesity, and it is also a potentially life threatening disease because of adrenal insufficiency. 28915118 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Taken together, we provide the first direct evidence for a diet-dependent deterioration of Ca<sup>2+</sup> homeostasis in POMC neurons during obesity development resulting in impaired function of these critical energy homeostasis-regulating neurons. 28762947 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE Overexpression of mIL-10 using AAV vector ameliorated obesity in parallel with restoration of ARC POMC expression in DIO mice. 27939689 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Our study demonstrated a great role of αMSH in adipocyte apoptosis and brings a new therapeutic mean to the treatment of obesity and diabetes. 28388573 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE In this review we discuss the importance of the brain POMC-MC4R system in regulating SNS activity and BP in obesity and other forms of hypertension. 28274841 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc<sup>-/-</sup>) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance. 29031726 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Similarly, selective deletion of the aPKC isoform <i>Pkc-λ</i> in proopiomelanocortin (POMC) neurons disrupts leptin action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin resistance specifically in HFD-fed male mice. 28073831 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Adrenocorticotropic hormone (ACTH)-secreting tumors account for 2% to 6% of adenomas and are associated with obesity, hypertension, diabetes, and other morbidity. 28170483 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Serum copeptin was significantly associated with HPA responsiveness in OB (post-CRH ACTH: R=0.42, P<0.01), driven by OB men (post-CRH ACTH: R=0.76, P<0.01, post-CRH cortisol: R=0.64, P=0.02). 28167369 2017
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin. 27468060 2016
CUI: C0028754
Disease: Obesity
Obesity
0.900 Biomarker disease BEFREE Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity. 27623943 2016
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE INPP5E, SNX17, ERAP2, FN3KRP), and obesity (e.g.POMC, CPEB4). 27193597 2016
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE The best interaction model for predicting obesity risk by MDR analysis was the three factor model including POMC (C > T), MC4R (T > C) and APOE (Hha1) polymorphisms. 26226973 2016
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Furthermore, both mutations PCSK1-p.Asn180Ser and POMC-p.Phe144Leu, which had previously been reported to be associated with severe obesity, were also identified in this study, but did not co-segregate with obesity. 24890885 2015
CUI: C0028754
Disease: Obesity
Obesity
0.900 AlteredExpression disease BEFREE Specific mutations in the leptin and the melaninocortin receptor genes in animal models of obesity without hypertension, the actions of α-melanocyte stimulating hormone, and SNS activity in obesity-related hypertension may promote recognition of protective and promoting factors for hypertension in obesity. 26103132 2015
CUI: C0028754
Disease: Obesity
Obesity
0.900 GeneticVariation disease BEFREE Therefore, these common variants in PCSK1 and POMC were not the major cause of obesity in the Thai subjects sampled. 26345846 2015