Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Activation of the dopamine receptor type-2 (DRD2) promoter by 9-cis retinoic acid in a cellular model of Cushing's disease mediates the inhibition of cell proliferation and ACTH secretion without a complete corticotroph-to-melanotroph transdifferentiation. 24926820 2014
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Hormonal tests confirmed adrenocorticotropic hormone (ACTH)-dependent Cushing disease. 27901643 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE In human patients, somatic mutations in USP8 were identified as the underlying cause of adrenocorticotropic hormone (ACTH) releasing pituitary adenomas causing Cushing's disease (CD). 31845722 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease CTD_human Cushing disease, which is caused by the excessive production of ACTH, is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment. 16809932 2006
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The primary cause of Cushing's disease is adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. 28919782 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease. 29027854 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE In each section, we endeavor to correlate basic mechanisms of ACTH function with the pathological consequences of ACTH signaling deficiency and of overproduction of ACTH. 26793988 2016
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a condition characterized by excess glucocorticoid from an ACTH pituitary adenoma. 29716804 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. 25942479 2015
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The selective expression of sst(5) receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing's disease. 15817922 2005
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE This case illustrates that ACTH stimulation by desmopressin is not specific for pituitary-dependent Cushing's syndrome as vasopressin receptor subtypes known to interact with desmopressin may also be found in ectopic tumours producing ACTH. 9425403 1997
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The study included adult patients admitted for evaluation of suspected CS (n=85), that were divided into 3 groups: CD (n=22), ACTH-independent CS from an adrenal tumor/hyperplasia (adrenal CS, n=21), and a control group consisting of subjects with negative screening for CS (rule-out CS, n=42). 28226363 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The diagnosis of acromegaly and adrenocorticotropin hormone-dependent Cushing's disease was confirmed. 31505284 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a rare endocrine condition caused by a corticotroph pituitary tumor that produces adrenocorticotropic hormone. 31701434 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Its diagnosis relies on both biochemical tests (high-dose dexamethasone suppression test, ACTH level, corticotropin-releasing hormone test) to confirm ACTH-dependent CD and image studies (CT or MRI of chest, abdomen, and/or pelvis) for source localization. 31019854 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a spectrum of clinical manifestations due to adrenocorticotropic hormone-secreting pituitary adenoma. 31491582 2020
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Pharmacological targeting of HSF1 may be a promising treatment option for the control of excess ACTH secretion in CD. 30995664 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. 28382019 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE However, cultures taken from all four ACTH-dependent and the one food-dependent hyperplastic adrenals studied were also responsive to GIP (EC50 for cAMP, 1.3 x 10(-9) M in Cushing's disease and 4.1 x 10(-10) M in food-dependent disease). 15705925 2005
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Exaggerated adrenocorticotropic hormone (ACTH) and cortisol responses to ghrelin in Cushing's disease (CD) have previously been reported, similarly to responses to corticotropin-releasing hormone (CRH). 26836811 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The predominant cause is adrenal adenoma (sometimes without decreased ACTH), rather than Cushing's disease. 29523633 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Nelson's syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing's disease. 8550738 1996
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH-dependent Cushing's syndrome is due to ACTH overproduction originating from a pituitary corticotroph adenoma (Cushing's disease) or from ectopic tumors (ectopic ACTH syndrome). 18075284 2007
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. 19655257 2011