Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease. 29027854 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE In each section, we endeavor to correlate basic mechanisms of ACTH function with the pathological consequences of ACTH signaling deficiency and of overproduction of ACTH. 26793988 2016
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a condition characterized by excess glucocorticoid from an ACTH pituitary adenoma. 29716804 2018
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease LHGDN POMC and Tpit mRNA levels were greater in CD and SCA than those in NFT. 18057378 2007
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease BEFREE Using quantitative real-time PCR, various ACTH-related gene expressions in tumor tissues from CD, subCD, and NFT were measured such as pro-opiomelanocortin (POMC), POMC transcription factor (Tpit, Pitx1, NeuroD1, and Nur77), POMC peptide processing enzymes (prohormone convertase: PC1/3 and PC2), and ACTH secretion-related factors (corticotropin-releasing hormone receptor 1: CRHR1 and glucocorticoid receptor α: GRα). 27025408 2016
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. 25942479 2015
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The selective expression of sst(5) receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing's disease. 15817922 2005
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE This case illustrates that ACTH stimulation by desmopressin is not specific for pituitary-dependent Cushing's syndrome as vasopressin receptor subtypes known to interact with desmopressin may also be found in ectopic tumours producing ACTH. 9425403 1997
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE Cushing disease (CD) is a rare entity caused by ACTH-secreting pituitary tumours, leading to prolonged hypercortisolism. 29927501 2018
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The study included adult patients admitted for evaluation of suspected CS (n=85), that were divided into 3 groups: CD (n=22), ACTH-independent CS from an adrenal tumor/hyperplasia (adrenal CS, n=21), and a control group consisting of subjects with negative screening for CS (rule-out CS, n=42). 28226363 2017
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease BEFREE Higher ACTH levels before treatment predicted a recurrence of CD. 28029519 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE The diagnosis of acromegaly and adrenocorticotropin hormone-dependent Cushing's disease was confirmed. 31505284 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a rare endocrine condition caused by a corticotroph pituitary tumor that produces adrenocorticotropic hormone. 31701434 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Its diagnosis relies on both biochemical tests (high-dose dexamethasone suppression test, ACTH level, corticotropin-releasing hormone test) to confirm ACTH-dependent CD and image studies (CT or MRI of chest, abdomen, and/or pelvis) for source localization. 31019854 2019
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease BEFREE The purpose of this study was to determine the association of hypokalemia with cortisol and ACTH levels in patients with CD. 31456238 2020
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE OBJECT Functional corticotroph pituitary adenomas (PAs) secrete adrenocorticotropic hormone (ACTH) and are the cause of Cushing's disease, which accounts for 70% of all cases of Cushing's syndrome. 25639319 2015
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Cushing's disease (CD) is a spectrum of clinical manifestations due to adrenocorticotropic hormone-secreting pituitary adenoma. 31491582 2020
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease BEFREE Moreover, clinical manifestations of CD may vary depending on hormonal activity; however, factors involved in the hormonal aggressiveness of adrenocorticotropic hormone (ACTH)-secreting pituitary tumors have not been fully clarified. 30474823 2019
Pituitary-dependent Cushing's disease
0.400 AlteredExpression disease BEFREE We speculate that the response to the desmopressin test observed in patients with Cushing's disease may be due to abnormal expression of V3R or V2R in ACTH-secreting tumors. 8626831 1996
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Pharmacological targeting of HSF1 may be a promising treatment option for the control of excess ACTH secretion in CD. 30995664 2019
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. 28382019 2017
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE However, cultures taken from all four ACTH-dependent and the one food-dependent hyperplastic adrenals studied were also responsive to GIP (EC50 for cAMP, 1.3 x 10(-9) M in Cushing's disease and 4.1 x 10(-10) M in food-dependent disease). 15705925 2005
Pituitary-dependent Cushing's disease
0.400 Biomarker disease BEFREE Exaggerated adrenocorticotropic hormone (ACTH) and cortisol responses to ghrelin in Cushing's disease (CD) have previously been reported, similarly to responses to corticotropin-releasing hormone (CRH). 26836811 2017
Pituitary-dependent Cushing's disease
0.400 GeneticVariation disease BEFREE The primary treatment of Cushing disease (hypercortisolism due to ACTH-producing adenomas, which is the cause in approximately 65% of the cases of hypercortisolism) is adenoma resection and medical therapies including ketoconazole, mifepristone, and pasireotide. 28170483 2017