|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
ACTH did not affect the clinical and biochemical outcomes in APA patients.
|
30601318 |
2019 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Adrenal tissues were obtained from patients with Cushing disease, ectopic secretion of ACTH [paraneoplastic Cushing syndrome; (paraCS)], 21-hydroxylase deficiency (21-OHD), primary bilateral macronodular adrenal hyperplasia with intra-adrenal ACTH presence, or cortisol-producing adenomas.
|
31074783 |
2019 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
And the remission rates were 87.5% (7/8) and 100% (3/3) for GH-secreting adenomas and ACTH-secreting adenomas respectively achieved by transsphenoidal surgery.
|
30637623 |
2019 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Radiation therapy (RT) is an effective treatment for patients with either nonfunctioning or secreting pituitary adenomas unsuccessfully treated by surgery and/or medical therapy, resulting in local control of 90-95% at 5-10 years and variable normalization of hormonal hypersecretion for patients with GH-, ACTH-, and prolactin-secreting adenomas in the range of 40-80% at 5 years; however, its use has been limited because of concerns regarding potential late toxicity of radiation and delayed efficacy in normalization of hormone hypersecretion.
|
31053487 |
2019 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Among the WHO 2017 special PA subtypes, patients with silent corticotroph adenoma had a lower event-free survival than ACTH-negative nonfunctional adenomas.
|
31432313 |
2019 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The biochemical remission rate in growth hormone secreting adenoma was 57%, in adrenocorticotropic hormone adenoma 67%, and prolactinoma 40%.
|
29574220 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Cushing's disease is primarily caused by pituitary adrenocorticotropin‑secreting adenoma.
|
29620167 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Common pituitary tumours were prolactin-secreting adenomas (45%), non-functioning pituitary adenomas (NFPAs: 35.6%), growth hormone (GH)-secreting adenomas (10.6%), craniopharyngiomas (7%), and adrenocorticotropic hormone (ACTH)-secreting adenomas (1.8%).
|
29858852 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This report describes a paediatric patient population with MEN1 in whom CD was the initial manifestation, confirming a previous observation that paediatric patients with MEN1 may present first with an ACTH-producing adenoma.
|
29927501 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
RESULTS Forty-eight surgical specimens contained an adenoma (46 ACTH-staining adenomas, 1 prolactinoma, and 1 nonfunctioning microadenoma).
|
28452619 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Postoperative Diabetes Insipidus and Hyponatremia in Children after Transsphenoidal Surgery for Adrenocorticotropin Hormone and Growth Hormone Secreting Adenomas.
|
29395172 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Visualization of microadenomas on preoperative imaging and confirmation of ACTH-positive adenomas have been associated with higher remission rates.
|
29754635 |
2018 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MATERIAL AND METHODS Sixty-six patients with pituitary null cell macroadenoma (1-3 cm diameter) (N=38) and pituitary null cell giant adenoma (≥3 cm diameter) (N=28) had preoperative and postoperative data including magnetic resonance imaging (MRI) and measurement of six pituitary hormones levels, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
|
30397189 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Coexisting pituicytoma and adrenocorticotropic hormone adenoma were identified in one patient with a diagnosis of Cushing disease.
|
29749277 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS) with bilateral cortisol-secreting adenomas has been rarely reported in the literatures.
|
29685132 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Remission rates were 100% (6/6 patients) for the ACTH cell adenoma group and 75% (12/16) for the group without adenoma.
|
29219752 |
2018 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Integrating DNA methylation and gene-expression data revealed that hypomethylation of promoter regions are related with increased expression of <i>GH1</i> and <i>SSTR5</i> genes in GH-secreting adenomas and <i>POMC</i> gene in ACTH-secreting adenomas.
|
30084836 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Cushing's disease (CD) is a rare disabling condition caused by Adrenocorticotropic hormone (ACTH)-secreting adenomas of the pituitary.
|
28850717 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Seven of the 13 patients with post-operative CSF rhinorrhoea did not experience intra-operative CSF leakage; three of these patients had adrenocorticotropic hormone-secreting adenomas.
|
28872159 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to assess whether miR-106b~25 and MCM7 levels correlate with tumor invasiveness in a cohort of ACTH-immunopositive adenomas.
|
28432562 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
First Report of Coexistence of Two Ectopic Pituitary Tumors: Rathke Cleft Cyst and Silent Adrenocorticotropic Hormone Adenoma.
|
28532906 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
HPA data of patients with SCAs (n = 38) were compared to others (Controls) with non-secreting, ACTH-negative immunostaining adenomas of similar age and gender distribution (n = 182) who had adenomectomy.
|
28528397 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Of the remaining 72 cases with sufficient tissue for further analysis, four were Pit-1 positive (6% of the adenomas negative for ACTH, prolactin, growth hormone, TSH, and SF-1); the remaining 68 were potentially null cell adenomas.
|
28994039 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Adrenocorticotropic hormone (ACTH)-secreting tumors account for 2% to 6% of adenomas and are associated with obesity, hypertension, diabetes, and other morbidity.
|
28170483 |
2017 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gene expression analysis of a transsphenoidal surgery sample of the pituitary gland revealed that ACTH-related genes, such as POMC, Tpit, and NeuroD1 mRNA, had higher expression in the tumor tissue than the nonfunctional adenoma but lower expression compared to an adenoma of typical Cushing's disease.
|
28865461 |
2017 |