Adrenal cortical hypofunction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients were divided into 3 groups according to the serum cortisol response to the rapid ACTH test; those with a peak serum cortisol level of <15 μg/dL were defined as the adrenal insufficiency (AI) probable group, ≥15 μg/dL and <18 μg/dL as the AI suspected group, and ≥18 μg/dL as the non-AI group.
|
31597820 |
2020 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>ABSTRACT</b><b>Objective:</b> To evaluate the performance of morning serum cortisol (MSC) compared to a 10 μg ACTH stimulation test in the diagnosis of adrenal insufficiency (AI).
|
31461355 |
2020 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Salivary cortisol levels by tandem mass spectrometry during high dose ACTH stimulation test for adrenal insufficiency in children.
|
31535345 |
2020 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
In both groups, none of the patients who had sufficient preoperative ACTH without hydrocortisone supplementation (n=15) showed hypocortisolism in the immediate postoperative measurement.
|
31453876 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
An ACTH stimulation test is the standard diagnostic test for adrenal insufficiency (AI).
|
31738804 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary AI is defined by the inability of the adrenal cortex to produce sufficient amounts of glucocorticoids and/or mineralocorticoids despite normal or increased adrenocorticotropin hormone (ACTH).
|
30120786 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
The subsequent evidence of low plasmatic and urinary cortisol and increased ACTH required the start of Hydrocortisone replacement therapy and it defined a clinical picture of adrenal insufficiency.
|
31164167 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We compared AI determination in cirrhotic patients with the ACTH test using these SaC thresholds versus established TSC thresholds (TSC-T<sub>0</sub>< 9 <i>μ</i>g/dl [248 nmol/L], TSC-T<sub>60</sub> < 18 <i>μ</i>g/dl [497 nmol/L], or ΔTSC<9 <i>μ</i>g/dl [248 nmol/L]).SaC correlated well with TSC.
|
31320899 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On an outpatient visit, serum ACTH and cortisol levels were normal despite the discontinuation of fludrocortisone and so the patient had been evaluated as partial adrenal insufficiency secondary to PD-related peritonitis.
|
31291617 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is important to recognize that relative adrenal insufficiency (AI) is the most common cause of low cortisol levels and failed ACTH challenge in ill patients.
|
31567142 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In previous reports, most cases of immune checkpoint inhibitor (ICI)-induced hypophysitis were diagnosed based on adrenal insufficiency symptoms or hyponatremia with low ACTH and cortisol.
|
31217401 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our systematic literature search revealed 9 studies (n = 371) that evaluated AI using adrenocorticotropic hormone stimulation testing, with measures of serum cortisol levels at baseline and following at least 2 weeks of TCS application.
|
30694073 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Postoperative ACTH stimulation testing to identify patients with AI.
|
31225874 |
2019 |
Adrenal cortical hypofunction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the POMC gene were linked with a clinical phenotype of adrenal insufficiency, red hair pigmentation, early onset and rapidly progressive obesity, early onset type 2 diabetes, hypothyroidism, hypogonadism and growth hormone deficiency.
|
29858905 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite widespread use of the 250-mcg Cosyntropin test (ACTH test) for the diagnosis of adrenal insufficiency (AI), the effect of time of day and the utility of performing both 30- and 60-min serum cortisol values remains unclear.
|
29458002 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult patients with β-thalassemia major.
|
29572711 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) stimulation test revealed 87 patients (24.23%) to have AI.
|
29806602 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the potential role of measuring salivary cortisol when adrenal insufficiency (AI) is suspected, to reduce the numbers of ACTH stimulation tests.
|
29531158 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we reported a 12-year-old female patient that was initially presented with unusual skin darkening and low serum level of adrenocorticotropic hormone and diagnosed as having adrenocortical insufficiency.
|
29181760 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
The High Dose Adrenocorticotropic Hormone (ACTH) Stimulation Test is the gold standard to diagnose adrenal insufficiency.
|
29476665 |
2018 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe here a case of pro-opiomelanocortin (POMC) deficiency in which adrenal insufficiency was not treated until the fourth year of life.
|
27906547 |
2017 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
By protocol, the first group received steroids in step 3 of the treatment according to the current international guidelines (group A), and the second group was managed as group A and was tested for AI by adrenal stimulation test using intramuscular adrenocorticotropic hormone (cosyntropin) (group B).
|
27798546 |
2017 |
Adrenal cortical hypofunction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The models of (i) 1-mg DST >138 nmol/l or (ii) >61 nmol/l with the presence of one among low levels of ACTH and dehydroepiandrosterone-sulphate had the highest accuracy (89·9%, P < 0·001) and odds ratio [OR 111·62, 95% confidence interval (CI) 21·98-566·74, P < 0·001] for predicting postsurgical hypocortisolism.
|
27341314 |
2017 |
Adrenal cortical hypofunction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygous mutations in the POMC gene is associated with hyperphagia, severe and early-onset obesity, adrenal insufficiency, hypopigmentation of the skin and red hair.
|
28915118 |
2017 |
Adrenal cortical hypofunction
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adrenal insufficiency is characterised by inadequate -glucocorticoid production owing to destruction of the adrenal cortex or lack of adrenocorticotropic hormone stimulation.
|
28572228 |
2017 |