POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE Pre-operative magnetic resonance imaging demonstrated sphenoid and/or cavernous sinus invasion in 44%, 33% were > 50% cystic, and 28% had high ACTH levels pre-operatively. 29032459 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Levels of urinary free cortisol, midnight serum cortisol, and adrenocorticotropic hormone, as well as tumor size and frequency of invasion of the cavernous sinus, were not significantly different between the two groups. 28505279 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE In the 196 cases of tested HCC samples, FLOT1 protein level was positively correlated with Tumor size (P = 0.025), clinical stage (P<0.002), CLIP stage (P<0.001), vascular invasion (P<0.001), relapse (P<0.001), and serum AFP levels (P = 0.025). 23840303 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Despite stimulating the invasion and EMT, exogenous HDGF supply only partially attenuated the POMC-mediated invasion inhibition and EMT change in melanoma cells. 23468531 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE Expression of several keratinocyte-derived mitogenic growth factors (Et-1, Hgf, Scf, α-MSH and Fgf 2 ) was elevated in skin of bigenic mice, whereas Fas, E-cadherin and Pten, implicated in apoptosis, cellular invasion and melanomagenesis, respectively, were downregulated within the microdissected melanocytic tumors. 20629968 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE Syndecan-2 expression was enhanced by fibroblast growth factor-2, which is known to stimulate melanoma cell migration; however, alpha-melanocyte-stimulating hormone decreased syndecan-2 expression and melanoma cell migration and invasion in a melanin synthesis-independent manner. 19641225 2009
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE Abnormal NPP expression is involved in pathological mineralization, crystal depositions in joints, invasion and metastasis of cancer cells, and type 2 diabetes. 12757929 2003
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 Biomarker phenotype BEFREE This tumor stained positive for ACTH by immunohistochemistry and was considered highly aggressive, demonstrating invasion beyond the sella turcica; however, when other ACTH-staining and invasive pituitary tumors were examined, no abnormality in the expression of c-fos was detected. 8027238 1994