|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, the inhibitory effect of pasireotide on ACTH secretion in corticotropinoma cells seems to be mainly mediated by SST<sub>5</sub>.
|
30483918 |
2019 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study population was compared to two control groups composed of patients cured after the resection of the ACTH secreting pituitary adenoma (Group A: 44 patients) and of the ACTH-secreting neuroendocrine tumours (Group B: 8 patients).
|
31583577 |
2019 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In pregnancy, the adrenal origin is the most frequent in up to 60% of the cases, in contrast to ACTH-secreting corticotroph adenomas of the pituitary gland, which account for 70% of the cases outside pregnancy.
|
29442480 |
2018 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similar to USP8 mutants, both USP48 and BRAF mutants enhance the promoter activity and transcription of the gene encoding proopiomelanocortin (POMC), which is the precursor of ACTH, providing a potential mechanism for ACTH overproduction in corticotroph adenomas.
|
30093687 |
2018 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
F-choline PET/CT revealed increased radiopharmaceutical uptake in a nodule localized in the left maxillary sinus, which was proved at histology to be an ectopic ACTH-secreting pituitary adenoma staining positive for ACTH.
|
29189371 |
2018 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we describe the first case of a patient with CNC and adrenocorticotropic hormone (ACTH)-dependent Cushing disease due to a pituitary corticotroph adenoma.
|
28522647 |
2017 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cushing's disease (CD) is caused by a corticotroph adenoma of the pituitary gland that secretes excess adrenocorticotropic hormone (ACTH) causing increased morbidity and mortality.
|
27894193 |
2017 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas.
|
27220856 |
2017 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cushing's disease (CD) results from uncontrolled hypercortisolism induced by ACTH-secreting corticotroph adenomas; accordingly, patients diagnosed with CD usually present several comorbidities and an increased risk of mortality.
|
26208471 |
2016 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
USP8 mutants diminished epidermal growth factor receptor ubiquitination and induced Pomc promoter activity in immortalized AtT-20 corticotropinoma cells.
|
25942478 |
2015 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intensity was lowest in the silent subtypes (silent corticotroph subtypes 1 and 2) compared with nontumorous human adenohypophysial corticotrophs, whereas the endocrinologically active subtypes (ACTH-secreting adenomas, corticotroph carcinomas, Crooke cell adenomas, Crooke cell carcinomas), showed the highest hK10 immunoexpression.
|
25517869 |
2015 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cushing disease is a neuroendocrine condition caused by partially glucocorticoid-resistant corticotroph adenomas that excessively secrete ACTH, which leads to hypercortisolism.
|
25665180 |
2015 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) production by pituitary corticotroph adenomas is the main cause of Cushing's disease.
|
25011056 |
2014 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the effects of a combination of 9-cis RA and Br on ACTH synthesis/secretion and cell viability in AtT20, and on POMC transcriptional activity in human corticotropinomas might represent a suitable starting point for assessing the potential of this treatment regimen for ACTH-secreting pituitary adenomas.
|
24926820 |
2014 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated receptor mRNA and protein expression levels and effects of octreotide, pasireotide, and cabergoline on ACTH secretion by cultured human corticotroph adenoma cells.
|
24081741 |
2013 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas.
|
21356276 |
2011 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical, hormonal and molecular characterization of pituitary ACTH adenomas without (silent corticotroph adenomas) and with Cushing's disease.
|
20385723 |
2010 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case highlights the relationship between FGD and hyperplasia of ACTH-producing cells, potentially leading to histologically proven pituitary corticotroph adenomas.
|
19423561 |
2009 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas.
|
19318729 |
2009 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ACTH-dependent Cushing's syndrome is due to ACTH overproduction originating from a pituitary corticotroph adenoma (Cushing's disease) or from ectopic tumors (ectopic ACTH syndrome).
|
18075284 |
2007 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Differential gene expression in ACTH -secreting and non-functioning pituitary tumors.
|
18057378 |
2007 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Molecular investigation of the normal mechanism of Gc feedback led to identification of two essential proteins for pro-opiomelanocortin repression that are often mis-expressed in corticotroph adenomas thus providing a molecular explanation for Gc resistance.
|
17718852 |
2007 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective expression of sst(5) receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing's disease.
|
15817922 |
2005 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization studies demonstrated that TPIT transcripts were coexpressed with POMC mRNA in both secreting and silent corticotroph adenomas, and in normal corticotrophs, whereas TPIT mRNA was not detectable in other types of pituitary adenomas.
|
12843142 |
2003 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results provide further evidence compatible with an ACTH feedback loop in the pituitary and suggest that loss of expression of the ACTH-R in corticotroph adenomas of patients with Cushing's disease may play a role in the resistance to feedback of the pituitary-adrenal axis seen in these patients.
|
14671214 |
2003 |