Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prevalence and features of growth disturbance will be discussed in ACTH-dependent and ACTH-independent Cushing's syndrome, adrenocortical tumours, premature adrenarche, congenital adrenal hyperplasia and adrenal insufficiency disorders.
|
31747461 |
2020 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Undetectable ACTH and unsuppressed cortisol levels by dexamethasone suggested ACTH-independent Cushing's syndrome.
|
31208392 |
2019 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the basis of these findings, we hypothesized that the use of a glucocorticoid receptor (GR) antagonist before surgery in ACTH-independent CS would rapidly activate the hypothalamic-pituitary-adrenal (HPA) axis and residual adrenal function.
|
30915117 |
2019 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hormonal tests suggested the presence of adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome.
|
30911452 |
2019 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adrenal vein sampling (AVS) is a good way to diagnose ACTH-independent CS.
|
31119141 |
2019 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
AVS adjusted by plasma aldosterone could be a useful technique in diagnosing ACTH-independent CS with bilateral adrenal adenomas prior to surgery.
|
29685132 |
2018 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case reminds clinicians to be aware of ectopic site in the diagnosis of adrenocorticotropic hormone (ACTH) independent Cushing's syndrome.
|
30557981 |
2018 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In-suite cortisol monitoring facilitates the use of adrenal vein sampling (AVS) for the differential diagnosis of primary aldosteronism and adrenocorticotropic hormone (ACTH)-independent Cushing syndrome.
|
29357735 |
2018 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary macronodular adrenal hyperplasia (PMAH), also known in the past as bilateral macronodular adrenalhyperplasia or adrenocorticotropin (ACTH)-independent macronodular adrenal hyperplasia, is a rare type of Cushing's syndrome (CS) and is associated with bilateralenlargement of the adrenal glands.
|
29279458 |
2018 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study included adult patients admitted for evaluation of suspected CS (n=85), that were divided into 3 groups: CD (n=22), ACTH-independent CS from an adrenal tumor/hyperplasia (adrenal CS, n=21), and a control group consisting of subjects with negative screening for CS (rule-out CS, n=42).
|
28226363 |
2017 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed whole-exome sequencing of 49 blood-tumor pairs and RNA sequencing of 44 tumors from cortisol-producing adrenocortical adenomas (ACAs), adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasias (AIMAHs), and adrenocortical oncocytomas (ADOs).
|
24700472 |
2014 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of the present study are to discuss the clinical and molecular findings of two Brazilian patients with ACTH-independent CS due to PPNAD and to show the diagnostic challenge CS represents in childhood.
|
20924687 |
2011 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
She was found to have adrenocorticotropic hormone (ACTH)-independent Cushing syndrome.
|
19833579 |
2010 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ACTH MC2 receptor showed a low expression in 15 of 18 AIMAHs samples, whereas several previously undescribed GPCR genes were found highly expressed in a subset of AIMAH, such as the receptors for motilin (MLNR; three of 18 AIMAHs) and γ-aminobutyric acid (GABBR1; five of 18 AIMAHs), and the α2A adrenergic receptor (ADRA2A; 13 of 18 AIMAHs), on which we focused our attention.
|
20660048 |
2010 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most common endocrine gland manifestations are acromegaly, thyroid and testicular tumors, and adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD).
|
16756677 |
2006 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic adrenal stimulation by ACTH in Cushing's disease or GIP in GIP-dependent ACTH-independent macronodular adrenal hyperplasia both lead to the induction of genes implicated in adrenal proliferation and steroidogenesis.
|
16772347 |
2006 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
AIMAH is a rare condition in which cortisol secretion may be mediated by non-ACTH circulating hormones such as gastric inhibiting polypeptide (leading to food-dependent Cushing's syndrome), vasopressin, catecholamines, luteinizing hormone, serotonin, angiotensin-II or leptin.
|
15666794 |
2004 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ACTH-independent macronodular adrenal hyperplasia (AIMAH) is an uncommon cause of Cushing's syndrome characterized by bilateral nodular adrenocortical hyperfunction in the presence of suppressed ACTH levels.
|
12727968 |
2003 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A 45-year-old woman with adrenocorticotropin (ACTH)-independent hypercortisolism, diabetes mellitus, and hypertension had undergone left adrenalectomy for ACTH-independent Cushing's syndrome 20 years prior to this presentation.
|
12670039 |
2002 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Control of cortisol secretion by the abnormal expression of the gastric inhibitory polypeptide receptor (GIP-R) have been observed in some rare cases of ACTH-independent, food-dependent Cushing's syndrome (FD-ACS) due to adrenal adenoma (AA) or bilateral macronodular hyperplasia (AIMAH).
|
11994328 |
2002 |
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma ACTH and dexamethasone suppression test results were consistent with ACTH-independent Cushing's syndrome, and a subsequent adrenalectomy revealed bilateral adrenocorticonodular hyperplasia.
|
8077378 |
1994 |