Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum PON1 activity levels were found to be significantly lower, and lipid peroxide concentrations significantly higher, in subjects with the metabolic syndrome compared with unaffected subjects (P = 0.033 and < 0.001, respectively).
|
14602783 |
2003 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two hundred and twenty-four subjects met the diagnostic criteria of MS. We found a significant interaction between MS and both the PON1 polymorphisms in determining the risk of coronary artery disease (P<0.05 by likelihood-ratio test).
|
15928879 |
2005 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Utility of sICAM-1 and PON1 as surrogate prognostic biomarkers and putative therapeutic targets in the management of diabetes and MetS is strongly suggested.
|
30327716 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no significant associations between PON1 Q192R genotypes and smoking by genotype interactions and obesity or overweight, while body mass index significantly increased MetS risk.
|
25037113 |
2014 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol.
|
28438472 |
2017 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
CTD_human |
Our results, in this first study, provide evidence for association of PON1 gene polymorphisms with the risk for metabolic syndrome.
|
21573798 |
2012 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results, in this first study, provide evidence for association of PON1 gene polymorphisms with the risk for metabolic syndrome.
|
21573798 |
2012 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
We used adenovirus-mediated PON1 gene transfer (AdPON1) to overexpress human PON1 in mice with combined leptin and LDL receptor deficiency, a model of metabolic syndrome.
|
16627808 |
2006 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders.
|
29393817 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied oxidized LDL (OxLDL), OxLDL/LDL, OxLDL/HDL, lipoperoxides, autoantibodies against OxLDL (OxLDL-Ab), diene formation of LDL (lag phase), vitamin E, vitamin E/cholesterol and PON1 polymorphisms (-108C>T, 55T>A, and 192A>G) in 166 non-smoking type 2 diabetic patients, 119 fulfilling the criteria for the metabolic syndrome, 73 with atherosclerosis and 93 without atherosclerosis.
|
17904830 |
2008 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Groups were evaluated at baseline for presence of MS, blood markers of metabolism, homeostasis model assessment of insulin resistance (HOMA-IR) score, and biochemical markers of inflammation (hs-CRP, IL-1β, IL-6, TNF-α and PON-1).
|
31134465 |
2019 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PON1 activities were influenced by all three polymorphisms, regardless of the presence of MS.
|
26193203 |
2015 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impaired paraoxonase-1 status in obese children. Relationships with insulin resistance and metabolic syndrome.
|
24028901 |
2013 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to our results, PON1 Q192R polymorphism is a risk marker for insulin resistance, a pathological factor involved in the development of metabolic syndrome.
|
25500007 |
2015 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The inverse relationship of PON-1 activity with free T<sub>4</sub> was not different in subjects with vs without MetS (P = .94), nor modified by the presence of its individual components (P ≥ .22 for each).
|
29171874 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |