Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Elevated concentrations of M-HDL particles and elevated levels of HDL-associated PON1 may contribute to long-term protection from the vascular complications of diabetes by pathways that are independent of total cholesterol and HDL cholesterol.
|
31597668 |
2020 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The increase percent of serum PON3 protein was higher than that of serum PON1 protein and the increase percent of serum lactonase activity was higher than that of serum paraoxonase and arylesterase activities in diabetes+lipoic acid group.We can report that, like PON1 protein, PON3 protein and actually its lactonase activity may also have a role as an antioxidant in diabetes mellitus and lipoic acid treatment may be useful for the prevention of the atherosclerotic complications of diabetes by increasing serum PON1 and PON3 protein levels and serum enzyme activities.
|
26849669 |
2019 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In multivariate analysis, PON1 paraoxonase activity was independently of confounding factors associated with diabetes (OR = 0.985; <i>p =</i> 0.024) and premature CHD in family history (OR = 0.983; <i>p =</i> 0.027).
|
30935088 |
2019 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated the effect of boron (B) as boric acid (BA) on body weight (b.w.); blood glucose; plasma insulin; lipase and paraoxonase (PON1) activities; and serum triglyceride, total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, lipid peroxidation (MDA), and total antioxidant capacity (TAC) in streptozotocin (STZ)-induced experimental diabetes in rats.
|
29019104 |
2018 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver.
|
29773198 |
2018 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Paraoxonase 1 (PON1), an arylesterase with antioxidant activity, has been shown to play an important role in preventing the development of diabetes in transgenic mice.
|
30269741 |
2018 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences.
|
29981194 |
2018 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Utility of sICAM-1 and PON1 as surrogate prognostic biomarkers and putative therapeutic targets in the management of diabetes and MetS is strongly suggested.
|
30327716 |
2018 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was a significant association between polymorphism C-108>T of PON1 and type2 diabetes mellitus, with 24.4% of control group subjects and 15.5% of patients having CC genotype; p<0.05.
|
28866115 |
2017 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The current data question the importance of PON-1 activity for the development of diabetes.
|
28732570 |
2017 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The aim of this study is to investigate whether and how PON1 glycation contributes to endothelial dysfunction in diabetes.
|
28374834 |
2017 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The serum PON1 activity was significantly decreased in the CAD group, the multiple coronary stenosis subgroup, and the diabetes mellitus subgroup compared with each control group.
|
28038449 |
2017 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa.
|
26009633 |
2015 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We showed a lower physiologically-significant lactonase PON1 activity in an Arab population, a finding consistent with the high cardiovascular and diabetes risk of Palestinians.
|
25801214 |
2015 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have shown that the Q192R polymorphism is a determinant of both PON1 concentration and activity and this association appeared to be enhanced in subjects with diabetes.
|
25477710 |
2014 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that PON1 may play a role in the onset and development of metabolic alterations in childhood obesity leading to diabetes and cardiovascular disease later in life.
|
24028901 |
2013 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the presence of metabolic syndrome and diabetes, PON1-192RR and PON2-311CC were associated with an increased risk of SCS and PON1-55MM seems to have lower risk.
|
23053877 |
2013 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These results further link PON1 to diabetes and inflammation and may inform the role of HDL in human disease.
|
23160181 |
2013 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was neither statistically significant association of PON1 polymorphisms with tumour stages nor with diabetes mellitus connected with PC.
|
23438848 |
2012 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found that PON1 Arg 192 and ACE D alleles act synergistically to increase the risk of CAD in CAD patients and CAD subjects without diabetes from west of Iran, who have high frequency of three-vessel disease.
|
21681430 |
2012 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Independent associations were: 1) PON1 activity negatively with insulin resistance, triglycerides and PON1-55 genotype and positively with PON1-192 genotype; 2) PON1 concentration negatively with Caucasian ethnicity, duration of diabetes and statin use and positively with plasma creatinine and PON1-192 genotype.
|
22846213 |
2012 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It has been shown that the serum PON1 concentration and activity are decreased in patients with both type 1 and type 2 DM.
|
21505009 |
2011 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Multiple linear regression analysis showed that LL genotype for PON1 (p < 0.03), high body mass index (BMI) values (p < 0.001) and low HDL-cholesterol levels (p < 0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels.
|
21231776 |
2011 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We quantified MDA levels and measured PON1 (paraoxonase/arylesterase) enzymatic activities in subjects suffering from cataract due to aging and diabetes.
|
19439227 |
2009 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PON1 A(-162)G and PON2 Ala148Gly genotypes, cystatin C, HbA1c, high density lipoprotein cholesterol (HDLC), waist circumference (waist), and duration of diabetes were included in the regression analysis with log(e) (ln) of PON1 mass as the dependent variable.
|
19151417 |
2009 |