PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Amyotrophic Lateral Sclerosis, Sporadic
0.350 GeneticVariation disease BEFREE The data from the present study suggest that these SNPs of the PON gene cluster do not contribute to the risk for developing SALS in a Chinese population. 22884547 2012
Amyotrophic Lateral Sclerosis, Sporadic
0.350 GeneticVariation disease BEFREE Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). 20381198 2011
Amyotrophic Lateral Sclerosis, Sporadic
0.350 GeneticVariation disease BEFREE The results did not show that the -A162G polymorphism of the PON1 gene is a risk factor of sALS in a Polish population; it may affect, however, bulbar onset of the disease. 20625960 2010
Amyotrophic Lateral Sclerosis, Sporadic
0.350 Biomarker disease BEFREE Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). 20582942 2010
Amyotrophic Lateral Sclerosis, Sporadic
0.350 AlteredExpression disease BEFREE Overall, promoter haplotypes that decrease PON1 expression were associated with SALS, whereas haplotypes that increase expression were associated with controls. 17204329 2007
Amyotrophic Lateral Sclerosis, Sporadic
0.350 Biomarker disease CTD_human A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. 17204329 2007