PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE Significant correlations between diabetes mellitus and paraoxonase activity (<i>R =</i> ⁻0.264, <i>p =</i> 0.026) and between the premature coronary heart disease in family history and PON1 activity (<i>R =</i> ⁻0.293, <i>p =</i> 0.013) were found. 30935088 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. 31400246 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE In the past few years, the Paraoxonase multigene family (<i>PON1, PON2, PON3</i>) has been shown to play an important role in pathogenesis of cardiovascular disorders including coronary artery disease (CAD). 31816846 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD. 31302193 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE The diagnostic performance of PON1 alone was comparable to that of the MPO/PON1 ratio for CAD risk assessment; however, MPO may increase the true positive rate. 30448568 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 PosttranslationalModification disease BEFREE Association of PON1 gene promoter DNA methylation with the risk of Clopidogrel resistance in patients with coronary artery disease. 30891852 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease. 30659791 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis. 29952962 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 PosttranslationalModification disease BEFREE We aimed to systematically investigate the role of genetic variations and DNA methylation of the PON1 CpG island promoter on the clinical outcomes of dual antiplatelet therapy for patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). 28875477 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE This study analyzed the association between the frequencies of genotypes of the L55 M and Q192 R SNPs in the PON1 gene with the PON1 activity and with CAD risk factors. 30853125 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE Furthermore, a Receiver Operating Characteristic Curve (ROC) analysis indicated that a PON1 activity cut-off point of 330 U/L could predict CAD with a sensitivity of 52% and a specificity of 65%. 28038449 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The <i>PON1</i> polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. 29118461 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The paraoxonase (PON) gene cluster (PC) protects against atherosclerosis and coronary artery diseases. 27578362 2016
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD. 26467378 2016
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease. 25155309 2016
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE We illustrate the proposed method through three meta-analyses for comparison of prostate cancer treatment, for the association between paraoxonase 1 activities and coronary heart disease, and for the association between homocysteine level and coronary heart disease. 25363629 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population. 25746376 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE This study provides further evidence that genetic variation of the LT pathway, PON1, and CYP1A1 can modulate the atherogenic processes and eventually increase the risk of CAD in our study population. 25902778 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE Paraoxonase 1 (PON1) is located on HDL.Meta-analysis of clinical epidemiological investigations reveals a substantial association of low serum PON1 activity with coronary heart disease incidence independent of other risk factors including HDL cholesterol and apolipoprotein AI (apoAI). 26103614 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE High-density lipoprotein (HDL) is also anti-atherosclerotic due to HDL associated paraoxonase-1 serum enzyme, which prevents LDL oxidative modifications and the development of CAD. 25470794 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE Low protective PON1 lactonase activity in an Arab population with high rates of coronary heart disease and diabetes. 25801214 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease. 25329996 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The relationship between PON gene polymorphisms and CAD was not conclusive, but most studies support the concept that alterations in PON1 enzymatic activity levels do influence atheroma formation. 25405733 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE High PON1 activity connected with the presence of CC and CT genotypes decreases the recurrence of symptoms of coronary heart disease and improve prognosis after CABG. 24721823 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE PON1 Q192R (rs662) had a significant effect on the risk of CAD (P=0.001). 24918121 2014