|
Leprosy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to investigate the association of variants in the TOLLIP gene with susceptibility to leprosy in Mexican patients.
|
24294608 |
2013 |
|
Necrotizing enterocolitis in fetus OR newborn
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of TLR2, TLR4, MyD88, TRAF-6, NFκB1 and IL-8 mRNA was increased while SIGIRR, IRAK-M, A-20 and TOLLIP mRNA were decreased in fetal vs. mature human enterocytes and further altered in NEC enterocytes.
|
21445298 |
2011 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
When AjTollip was co-transfected with AjMyD88 into HEK293 cells, the luciferase activities of NF-κB were significantly decreased compared with that of AjMyD88 single-transfection groups in natural state or under the stimulation of LPS and poly I:C. These results collectively suggested that AjTollip functions as a negative regulator of MyD88-dependent TLR signaling and plays an important role in fish defense against viral and bacterial infections.
|
31015066 |
2019 |
|
Legionnaires' Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that TOLLIP decreases lung-specific TLR responses to increase LD susceptibility in human populations.
|
31462698 |
2019 |
|
Legionella pneumophila pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.
|
31462698 |
2019 |
|
Aeromonas hydrophila infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The AjTollip expressions in the liver and kidney were significantly induced following injection with the bacterial mimic LPS, the viral mimic poly I:C, and Aeromonas hydrophila infection.
|
31015066 |
2019 |
|
Common Variable Immunodeficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We showed a lower mRNA expression of MyD88 and an almost equal Tollip mRNA expression in CVID patients compared with controls.
|
29757592 |
2018 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Factors involved in inhibition of NF-κβ, such as A20 and TOLLIP, are also affected in IBD, resulting in failed inflammation suppression/regulation.
|
30425977 |
2018 |
|
Tuberculosis, Pulmonary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For TOLLIP, rs5743899 (p = 0.005, OR = 1.83, 95% CI: 1.20-2.80) CC genotype were risk factors for PTB progression.
|
29924447 |
2018 |
|
Extrinsic allergic alveolitis
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The minor allele frequency (MAF) was greater for MUC5B rs35705950 in patients with chronic hypersensitivity pneumonitis than in healthy controls (24·4% in UCSF and 32·3% in UTSW vs 10·7%, both p<0·0001), but not for TOLLIP rs5743890.
|
28648751 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that Tollip may play a crucial role in sustaining neuron health by facilitating the completion of autophagy, and that Tollip-deficiency may accelerate neuron death related to neurological disease such as Alzheimer's disease.
|
27720815 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a significant role in lipophagy and modulate lipid accumulation during the pathogenesis of atherosclerosis and liver steatosis.
|
28396568 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a significant role in lipophagy and modulate lipid accumulation during the pathogenesis of atherosclerosis and liver steatosis.
|
28396568 |
2017 |
|
Mental Depression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we sought to investigate the association of depression severity, measured by the 17-item Hamilton Depression Rating Scale (HAMD-17), with mRNA expression levels of negative regulators of the TLR pathway, including SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2 and TNFAIP3, in peripheral blood mononuclear cells (PBMCs) from 100 patients with MDD and 53 healthy controls, before and after treatment with antidepressants.
|
27640899 |
2017 |
|
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we sought to investigate the association of depression severity, measured by the 17-item Hamilton Depression Rating Scale (HAMD-17), with mRNA expression levels of negative regulators of the TLR pathway, including SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2 and TNFAIP3, in peripheral blood mononuclear cells (PBMCs) from 100 patients with MDD and 53 healthy controls, before and after treatment with antidepressants.
|
27640899 |
2017 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a significant role in lipophagy and modulate lipid accumulation during the pathogenesis of atherosclerosis and liver steatosis.
|
28396568 |
2017 |
|
Malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association of the TOLLIP rs3750920 T allele with susceptibility to malaria further provides evidence that genetic variations in immune response genes may predispose individuals to malaria.
|
28288644 |
2017 |
|
Malaria, Vivax
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, TOLLIP variants were investigated to their relation to Plasmodium vivax malaria in the Brazilian Amazon.
|
28288644 |
2017 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we sought to investigate the association of depression severity, measured by the 17-item Hamilton Depression Rating Scale (HAMD-17), with mRNA expression levels of negative regulators of the TLR pathway, including SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2 and TNFAIP3, in peripheral blood mononuclear cells (PBMCs) from 100 patients with MDD and 53 healthy controls, before and after treatment with antidepressants.
|
27640899 |
2017 |
|
Necrotizing Enterocolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats.
|
28056921 |
2017 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among them, eight upregulated proteins (RPN2, HSPA9, NPTN, AP2B1, UQCRC2, RACK-1, TOLLIP) and one downregulated protein, TLN2, were previously associated with MDD or antidepressant drug response in the literature.
|
28860968 |
2017 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule involved in the fusion of autolysosome, may play a significant role in lipophagy and modulate lipid accumulation during the pathogenesis of atherosclerosis and liver steatosis.
|
28396568 |
2017 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of both peroxisome proliferator-activated receptor gamma (PPARγ) and Toll interacting protein (Tollip) was decreased in both active and inactive UC and CD and at both mRNA and protein levels.
|
26462859 |
2016 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, expression of both peroxisome proliferator-activated receptor gamma (PPARγ) and Toll interacting protein (Tollip) was decreased in both active and inactive UC and CD and at both mRNA and protein levels.
|
26462859 |
2016 |
|
Leishmaniasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms rs5743899 and rs3750920 in the TOLLIP gene were genotyped by polymerase chain reaction and restriction fragment length polymorphism (RFLP) analysis in 631 patients with cutaneous leishmaniasis (CL) caused by L. guyanensis and 530 individuals with no history of leishmaniasis.
|
26107286 |
2015 |