POU2F1, POU class 2 homeobox 1, 5451

N. diseases: 115; N. variants: 7
Disease: Myeloid Leukemia, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.050 AlteredExpression disease BEFREE Low ABCB1 and high OCT1 levels play a favorable role in the molecular response to imatinib in CML patients in the community clinical practice. 27770655 2016
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.050 GeneticVariation disease BEFREE OCT1 genetic variants are associated with long term outcomes in imatinib treated chronic myeloid leukemia patients. 24215657 2014
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.050 AlteredExpression disease BEFREE OCT1 mRNA and protein expression were analyzed in leukemic cells from patients with imatinib-naïve CML as well as in cell lines. 24352644 2014
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.050 AlteredExpression disease BEFREE Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. 20147974 2010
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.050 AlteredExpression disease BEFREE We recently showed that low OCT-1 activity is a major contributor to suboptimal response in chronic myeloid leukemia (CML) patients treated with imatinib. 18559609 2008