Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
RIAM silencing in melanoma cells led to inhibition of tumor growth and to delayed metastasis in a severe combined immunodeficiency xenograft model.
|
21454517 |
2011 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
RIAM silencing in melanoma cells led to inhibition of tumor growth and to delayed metastasis in a severe combined immunodeficiency xenograft model.
|
21454517 |
2011 |
Severe Combined Immunodeficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIAM silencing in melanoma cells led to inhibition of tumor growth and to delayed metastasis in a severe combined immunodeficiency xenograft model.
|
21454517 |
2011 |
C-reactive protein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
|
22228203 |
2012 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
|
22566498 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development.
|
28348273 |
2017 |
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development.
|
28348273 |
2017 |
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development.
|
28348273 |
2017 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, because RIAM-null mice are healthy, fertile, and display no bleeding abnormalities, our results identify RIAM and its regulators as potential targets for therapies of T cell-mediated autoimmunity.
|
28348273 |
2017 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our present work demonstrate that LUT can suppresses autophagy but enhance apoptosis induced by cisplatin and promote the sensitivity to cisplatin through suppressing the expression of RARP1 in ovarian cancer.
|
29808795 |
2018 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our present work demonstrate that LUT can suppresses autophagy but enhance apoptosis induced by cisplatin and promote the sensitivity to cisplatin through suppressing the expression of RARP1 in ovarian cancer.
|
29808795 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our present work demonstrate that LUT can suppresses autophagy but enhance apoptosis induced by cisplatin and promote the sensitivity to cisplatin through suppressing the expression of RARP1 in ovarian cancer.
|
29808795 |
2018 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Mig-10/RIAM/lamellipodin (MRL) family member Rap1-GTP-interacting adaptor molecule (RIAM) interacts with active Rap1, a small GTPase that is frequently activated in tumors such as melanoma and prostate cancer.
|
21454517 |
2011 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Mig-10/RIAM/lamellipodin (MRL) family member Rap1-GTP-interacting adaptor molecule (RIAM) interacts with active Rap1, a small GTPase that is frequently activated in tumors such as melanoma and prostate cancer.
|
21454517 |
2011 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that inhibition of cell invasion in RIAM-silenced melanoma cells is likely based on altered cell contractility and cell polarization.
|
21454517 |
2011 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these data suggest that defective activation of these kinases in RIAM-silenced cells could account for inhibition of melanoma cell growth and that RIAM might contribute to the dissemination of melanoma cells.
|
21454517 |
2011 |