POU4F1, POU class 4 homeobox 1, 5457

N. diseases: 54; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.320 Biomarker disease CTD_human We observed that BRN3A is independent of the regulative activity of HIPK2 and undergoes positive autoregulation in cervical cancer cells. 21928122 2011
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.320 AlteredExpression disease BEFREE Dysregulation of the Pit/Oct/Unc (POU) domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML. 20376082 2010
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.320 AlteredExpression disease BEFREE AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia. 20460523 2010
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.320 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.320 Biomarker disease BEFREE These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening. 12911730 2004
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.320 AlteredExpression disease BEFREE The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV. 9541499 1998
CUI: C0206708
Disease: Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia
0.310 AlteredExpression disease BEFREE Importantly, women smokers with high levels of Brn-3a infected with low- or high-risk HPV-16 variants have augmented E6 levels, and were more frequently diagnosed with higher grades of cervical intraepithelial neoplasia (CIN) and cancer, as compared with non-smokers who were infected with similar variants and expressed similar levels of Brn-3a. 20190800 2010
CUI: C0206708
Disease: Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia
0.310 Biomarker disease CTD_human Therefore, this study defines the specific interplay between the cellular transactivator Brn-3a, the environmental smoking-related substance nicotine and specific HPV variants in cervical carcinogenesis, and thus helps to explain why some women are susceptible to rapid CIN progression and cancer and others are not. 20190800 2010
CUI: C0851140
Disease: Carcinoma in situ of uterine cervix
Carcinoma in situ of uterine cervix
0.310 Biomarker disease CTD_human The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix. 20190800 2010
CUI: C0851140
Disease: Carcinoma in situ of uterine cervix
Carcinoma in situ of uterine cervix
0.310 AlteredExpression disease BEFREE The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV. 9541499 1998
CUI: C0007873
Disease: Uterine Cervical Neoplasm
Uterine Cervical Neoplasm
0.300 Biomarker disease CTD_human Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells. 21928122 2011
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1
0.300 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2)
0.300 Biomarker disease CTD_human Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 18206229 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE In tumourigenic melanocytes and fibroblasts, Brn3a accelerated tumour growth in vivo. 23666755 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE In cancer cells, elevated transcription factor-related Brn-3a regulator isolated from brain cDNA (Brn-3b) transcription factor enhances proliferation in vitro and increases tumour growth in vivo whilst conferring drug resistance and migratory potential, whereas reducing Brn-3b slows growth both in vitro and in vivo. 21241485 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE This is a follow-up of our previous work in which for the first time Brn-3a and E6 levels in cervical smears from women in United Kingdom were shown to correlate with the histological diagnosis of cervical neoplasia and were even better in predicting underlying pre-malignant disease than conventional procedures. 16126264 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE We define the G-protein-coupled receptor RDC1 as a tumor endothelial marker whose expression is distinctly induced in tumor endothelial cells of both brain and peripheral vasculature. 15277233 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. 12893201 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 Biomarker group BEFREE Hence they establish Brn-3a as a key factor in cervical tumorigenesis and as a potential therapeutic target in human cervical neoplasia. 11521202 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE To test the role of Brn-3a in cervical neoplasia we have manipulated its expression in cervical carcinoma-derived cell lines with or without endogenous HPV genes. 10497216 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.080 AlteredExpression group BEFREE Although nine bronchial tumors produced POMC, there was no association between Brn3a levels and POMC gene expression; the two tumors with the highest POMC messenger ribonucleic acid contents were two bronchial carcinoids with barely detectable Brn3a levels. 8989239 1997
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.040 AlteredExpression disease BEFREE Here we show that the neuronal marker BRN3A/POU4F1 is expressed abundantly at the protein level in primary EFT but not in rhabdomyosarcoma and neuroblastoma, and EFT cells exhibit high activity of the BRN3A proximal autoregulatory region. 20348952 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.040 AlteredExpression disease BEFREE Similarly, reduction of Brn-3a expression using anti-sense constructs reduces endogenous p53 expression in human neuroblastoma or cervical carcinoma cell lines growing in vitro and as tumours in nude mice whilst increasing Brn-3a levels enhances p53 expression. 12431761 2002
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.040 AlteredExpression disease BEFREE Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation. 8782654 1996
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.040 AlteredExpression disease BEFREE In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas. 1357630 1992