cervical cancer
|
0.320 |
Biomarker
|
disease |
CTD_human |
We observed that BRN3A is independent of the regulative activity of HIPK2 and undergoes positive autoregulation in cervical cancer cells.
|
21928122 |
2011 |
Leukemia, Myelocytic, Acute
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Dysregulation of the Pit/Oct/Unc (POU) domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML.
|
20376082 |
2010 |
Leukemia, Myelocytic, Acute
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.
|
20460523 |
2010 |
Leukemia, Myelocytic, Acute
|
0.320 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
cervical cancer
|
0.320 |
Biomarker
|
disease |
BEFREE |
These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
|
12911730 |
2004 |
cervical cancer
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV.
|
9541499 |
1998 |
Cervical Intraepithelial Neoplasia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Importantly, women smokers with high levels of Brn-3a infected with low- or high-risk HPV-16 variants have augmented E6 levels, and were more frequently diagnosed with higher grades of cervical intraepithelial neoplasia (CIN) and cancer, as compared with non-smokers who were infected with similar variants and expressed similar levels of Brn-3a.
|
20190800 |
2010 |
Cervical Intraepithelial Neoplasia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Therefore, this study defines the specific interplay between the cellular transactivator Brn-3a, the environmental smoking-related substance nicotine and specific HPV variants in cervical carcinogenesis, and thus helps to explain why some women are susceptible to rapid CIN progression and cancer and others are not.
|
20190800 |
2010 |
Carcinoma in situ of uterine cervix
|
0.310 |
Biomarker
|
disease |
CTD_human |
The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix.
|
20190800 |
2010 |
Carcinoma in situ of uterine cervix
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV.
|
9541499 |
1998 |
Uterine Cervical Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.
|
21928122 |
2011 |
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In tumourigenic melanocytes and fibroblasts, Brn3a accelerated tumour growth in vivo.
|
23666755 |
2013 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In cancer cells, elevated transcription factor-related Brn-3a regulator isolated from brain cDNA (Brn-3b) transcription factor enhances proliferation in vitro and increases tumour growth in vivo whilst conferring drug resistance and migratory potential, whereas reducing Brn-3b slows growth both in vitro and in vivo.
|
21241485 |
2011 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
This is a follow-up of our previous work in which for the first time Brn-3a and E6 levels in cervical smears from women in United Kingdom were shown to correlate with the histological diagnosis of cervical neoplasia and were even better in predicting underlying pre-malignant disease than conventional procedures.
|
16126264 |
2006 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We define the G-protein-coupled receptor RDC1 as a tumor endothelial marker whose expression is distinctly induced in tumor endothelial cells of both brain and peripheral vasculature.
|
15277233 |
2004 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia.
|
12893201 |
2003 |
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Hence they establish Brn-3a as a key factor in cervical tumorigenesis and as a potential therapeutic target in human cervical neoplasia.
|
11521202 |
2001 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
To test the role of Brn-3a in cervical neoplasia we have manipulated its expression in cervical carcinoma-derived cell lines with or without endogenous HPV genes.
|
10497216 |
1999 |
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Although nine bronchial tumors produced POMC, there was no association between Brn3a levels and POMC gene expression; the two tumors with the highest POMC messenger ribonucleic acid contents were two bronchial carcinoids with barely detectable Brn3a levels.
|
8989239 |
1997 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the neuronal marker BRN3A/POU4F1 is expressed abundantly at the protein level in primary EFT but not in rhabdomyosarcoma and neuroblastoma, and EFT cells exhibit high activity of the BRN3A proximal autoregulatory region.
|
20348952 |
2010 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Similarly, reduction of Brn-3a expression using anti-sense constructs reduces endogenous p53 expression in human neuroblastoma or cervical carcinoma cell lines growing in vitro and as tumours in nude mice whilst increasing Brn-3a levels enhances p53 expression.
|
12431761 |
2002 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation.
|
8782654 |
1996 |
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas.
|
1357630 |
1992 |