POU4F1, POU class 4 homeobox 1, 5457

N. diseases: 54; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.030 AlteredExpression disease BEFREE Here we show that the neuronal marker BRN3A/POU4F1 is expressed abundantly at the protein level in primary EFT but not in rhabdomyosarcoma and neuroblastoma, and EFT cells exhibit high activity of the BRN3A proximal autoregulatory region. 20348952 2010
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.030 AlteredExpression disease BEFREE Similarly, reduction of Brn-3a expression using anti-sense constructs reduces endogenous p53 expression in human neuroblastoma or cervical carcinoma cell lines growing in vitro and as tumours in nude mice whilst increasing Brn-3a levels enhances p53 expression. 12431761 2002
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.030 AlteredExpression disease BEFREE Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation. 8782654 1996