Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AZD1775 also selectively inhibited the proliferation of patient-derived primary cell lines from gliomas with naturally occurring ATRX mutations, indicating that the synthetic lethal relationship between WEE1 and ATRX could be exploited in a broader spectrum of human tumors.
|
31551363 |
2020 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings reveal novel pathogenic mechanisms driven by ATRX deficiency in glioma, while also pointing to tangible strategies for drug development.
|
30808951 |
2019 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, CDKN loss, ATRX mutation and coexisting gain of chromosome 7/loss of chromosome 10 showed no clinical significance in this glioma entity.
|
30298540 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X-linked (ATRX) genes have been the subject of numerous studies on the classification and prognosis of glioma.
|
30655743 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Translation of these findings to patients with IDH1<sup>132H</sup> glioma harboring TP53 and ATRX loss could improve the therapeutic efficacy of radiotherapy and, consequently, patient survival.
|
30760578 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.
|
29545335 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner.
|
30226859 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
• ATRX in lower-grade gliomas could be predicted using radiomic analysis.
|
29404769 |
2018 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we performed ATRX-IHC in 78 gliomas whose ATRX statuses were comprehensively determined by whole exome sequencing.
|
29550880 |
2018 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The presence of ATRX mutations in glioma serves as a marker of better prognosis with longer patient survival although the underlying mechanisms are poorly understood.
|
29378238 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
p-Hsp27 is a novel biomarker of glioma and might have important clinical value for further classification of patients with wild-type IDH1 and normal ATRX expression, for evaluating prognosis and for guidance for adjuvant therapy.
|
29550762 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We anticipate new treatments and clinical approaches will emerge for glioma and other cancer types as mechanistic and molecular studies on ATRX are only just beginning to reveal the many critical functions of this protein in cancer.
|
29889582 |
2018 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations.
|
29521646 |
2018 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate arterial spin labeling (ASL) perfusion and dynamic contrast-enhanced (DCE) perfusion in glioma grading according to the previous WHO classification of 2007, as well as concerning isocitrate dehydrogenase (IDH) mutation status and ATRX expression as required by the new WHO 2016 brain tumor classification.
|
28488024 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
One hundred seventy six cases of glioma were assessed for ATRX immunohistochemistry and subdivided into positive, negative and mosaic/heterogeneous staining patterns.
|
26833422 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Role of ATRX in Glioma Biology.
|
29034211 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.
|
26936505 |
2016 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results indicate immunohistochemical analysis including IDH1/2, ATRX, p53, and Ki-67 index is valuable for the classification of diffuse gliomas, which is useful for the evaluation of prognosis, especially Grade III gliomas and lower-grade gliomas (i.e., Grade II and III).
|
26968173 |
2016 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results showed ATRX-related regulatory functions of the combined profiles from DNA methylation and mRNA expression in astrocytic tumors, and delineated that loss of ATRX impacted biological behaviors of astrocytic tumor cells, providing important resources for future dissection of ATRX role in glioma.
|
25971279 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subsequent subgroup analysis largely confirms many of the currently used molecular classification schemes for diffuse gliomas (ATRX or TP53 mutations, 1p19q codeletion).
|
26699864 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status.
|
24559763 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.
|
24705251 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
|
23583981 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In adults, ATRX aberrations were detected in 33 % of grade II and 46 % of grade III gliomas, as well as in 80 % of secondary and 7 % of primary GBMs.
|
22886134 |
2012 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.
|
23104868 |
2012 |