|
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
|
16491129 |
2006 |
|
Zellweger Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Recently, the use of experimental models led to the identification of a gene encoding for a peroxisomal membrane protein (PAF-1) in which a mutation was associated with the altered phenotype in a complementation group of the Zellweger syndrome (paradigm of these diseases).
|
8507691 |
1993 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Nephroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.
|
25099282 |
2014 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We find that Paf1 undergoes ubiquitylation and is degraded by the 26S proteasome in yeast, thus deciphering UPS regulation of an evolutionarily conserved factor, Paf1, involved in various cellular processes at the crossroads of the cancer networks.
|
29023102 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy.<i>Cancer Res; 78(2); 313-9.©2018 AACR</i>.
|
29311159 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways.
|
28657910 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy.<i>Cancer Res; 78(2); 313-9.©2018 AACR</i>.
|
29311159 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
We find that Paf1 undergoes ubiquitylation and is degraded by the 26S proteasome in yeast, thus deciphering UPS regulation of an evolutionarily conserved factor, Paf1, involved in various cellular processes at the crossroads of the cancer networks.
|
29023102 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways.
|
28657910 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Pt(II) and Pd(II) complexes with a thiazoline derivative ligand: Synthesis, structural characterization, antiproliferative activity and evaluation of pro-apoptotic ability in tumor cell lines HT-29 and U-937.
|
31689624 |
2020 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Our results indicate that hPaf1/PD2 is overexpressed in OCSCs and maintains the self-renewal of OCSCs through its interaction with OCT3/4; thus, hPaf1/PD2 may be a potential therapeutic target to overcome tumor relapse in OC.
|
28122356 |
2017 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The treatment of the Pd(II) complex in tumor-bearing mice effectively reduced the tumor size at half the dose used for cisplatin.
|
28657910 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Biological tests proved that Pd(II) complexes <b>1</b> and <b>2</b> (containing a curcumin derivative) exhibit a strong in vitro antitumor effect against the cells derived from human colorectal carcinoma and the hepatic metastasis of a colorectal carcinoma.
|
28358339 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, the results suggest that the new designed Pt(II) and Pd(II) complexes are well promising candidates for use in cancer treatment, particularly for human colorectal cancer.Communicated by Ramaswamy H. Sarma.
|
30146941 |
2019 |
|
Zellweger Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
This gene encodes a protein that shows similarity to the mammalian PAF1 protein (Zellweger syndrome).
|
7600573 |
1995 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 19q13 amplicon in pancreatic cancer cells contains a novel pancreatic differentiation 2 (PD2) gene (accession number AJ401156), which was identified by differential screening analysis.
|
16491129 |
2006 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 19q13 amplicon in pancreatic cancer cells contains a novel pancreatic differentiation 2 (PD2) gene (accession number AJ401156), which was identified by differential screening analysis.
|
16491129 |
2006 |