Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PPARα has prognostic significance only in ccRCC tumors. 31258735 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Whereas, after the addition of circPVT1, this effect no longer worked, suggesting that circPVT1 may affect the malignancy of the tumor by affecting miRNA and regulating the levels of Paxs and PPARs. 31636510 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth. 30565681 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PPARα agonist alleviates tumor growth and chemo-resistance associated with the inhibition of glucose metabolic pathway. 31539552 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation group BEFREE Our analysis reveals underappreciated levels of diversity and conservation in PPAR genes that could lay the groundwork for therapeutic strategies targeting tumor metabolism, immunity, and hypoxia. 31215667 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Upstream regulator analysis highlighted transcriptional regulation by peroxisome proliferator-activated receptor alpha (PPARα) in the liver and kidney and by tumor protein/suppressor p53 (TP53) in the thymus, spleen, and liver. 30186752 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE PPARα expression was unrelated to gonadotroph differentiation in NFPA, but positively correlated with tumour volume in PRL-PA. 30021235 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE We also found higher PPARα expression in the tumor area than adjacent areas and subsequently compared PPARα expression in four different hepatic cancer cell lines. 29134746 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Multivariate Cox analyses indicated that tumor size (<i>P</i>=0.001), TNM stage (<i>P</i><0.001), vascular invasion (<i>P</i><0.001), and PPARα expression in the cytoplasm (<i>P</i><0.001) were found to be independent prognostic variables for overall survival. 29983595 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PFCAs, especially those having longer carbon chain lengths (≥C6), are associated with developmental and hormonal effects, immunotoxicity, and promote tumor growth in rodents through their role as PPARα agonists. 27876672 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE 5) Peroxisome proliferators do not promote tumour formation in human liver as opposed to mouse liver because of structural and functional differences between human and mouse PPARα. 28077274 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Importantly, genetic knockouts of PPARα have been shown to be protected against tumor growth in a variety of syngeneic tumors models. 28483457 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PPARα was previously indicated by us as a potential therapeutic target for this neoplasm, due to the malignancy grade dependency of its expression, being particularly abundant in GB. 27736000 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE We further confirmed that depletion of PPARα resulted in low CPT1C expression and then inhibited proliferation and induced senescence of MDA-MB-231 and PANC-1 tumor cell lines in a CPT1C-dependent manner, while forced PPARα overexpression promoted cell proliferation and reversed cellular senescence. 28334197 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to disrupt tumour metabolism and to promote anticancer activity through interfering with the Warburg effect. 28453233 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Based on these studies, it was demonstrated that the liver tumors were mediated by a mode of action (MoA) involving nuclear receptors (NRs) through the following key events: (1) CAR and PPAR-α receptor activation, (2) increased hepatocellular proliferation, eventually leading to (3) hepatocellular tumors. 25092647 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PPARα is a nuclear receptor protein that functions as a transcription factor for genes including those encoding enzymes involved in energy metabolism; while PPARα has been reported to regulate tumor growth in several cancers, it has not been evaluated in RCC. 23951092 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Although PPARα expression was also increased in the n-3 PUFA-enriched diet group under docetaxel treatment, it is only the expression of PPARβ mRNA that correlated with the regression of mammary tumors: those that most regressed displayed the lowest PPARβ mRNA expression. 23906790 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE In conclusion, this study demonstrates that loss of expression of GMPR2 and PPARα is associated with BP at the protein level; indicating that they may play a role in carcinogenesis of this molecularly complex and clinically important subtype. 23208589 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Activation of peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to inhibit tumor growth and angiogenesis, yet the mechanisms behind these actions remain to be characterized. 22932900 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Administration of a novel NOX-specific inhibitor reduced angiogenesis and tumor growth in vivo in a PPARα dependent manner. 21326871 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Our findings may also reveal the possibility of using the level of endogenous PPARγ ligands and the activities of PPARγ or PPARα as tumor markers for lung cancer. 20081051 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression group BEFREE Optimal cutoff values were determined for each relative expression ratio (RER) (RER = PPAR expression of tumor/PPAR expression of normal mucosa) of PPAR, and patients were divided into two groups as follows (PPAR staging): patients with elevated RERs of PPAR gamma (> 2.0) or PPAR delta (> 1.0) were termed Group H, and patients showing none of these elevated RERs of PPARs were termed Group L. Prognostic significance was analyzed by univariate and Kaplan-Meier analyses. 19283612 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE PPARalpha activation causes inhibition of migration of melanoma cells and anchorage-independent growth, whereas primary tumor growth remains unaltered. 18092840 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker group BEFREE Thus, both genetic abrogation of PPARalpha as well as its activation by ligands cause tumor suppression via overlapping antiangiogenic pathways. 18199835 2008