|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that obesity attenuates lung antiviral immunity and hampers host recovery through the modulation of macrophage PPAR-<i>γ</i> expression.
|
31009317 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment.
|
30738174 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings establish a central role for HDAC3 in co-ordinating PPAR-regulated lipid oxidation in the intestinal epithelium, and identify intestinal HDAC3 as a potential therapeutic target for preventing obesity and related diseases.
|
31757939 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARα contributes to the CYP2A5 protective effects on fatty liver but it opposes to the protective effects on obesity.
|
29568101 |
2019 |
|
Obesity
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that GSK-3α promotes lipid anabolism through PPARα-Ser280 phosphorylation, which underlies the development of lipotoxic cardiomyopathy in the context of obesity.
|
30745182 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, the PPAR-γ2-RXR-α heterodimer showed weak activity and bound weakly to the putative IGFBP-2-PPRE promoter sequence in VAT from HIR-MO subjects when compared with LIR-MO individuals.
|
31547433 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both PPARα and GPR119 have potential as pharmacological targets for the treatment of obesity and the former for treatment of intestinal inflammation.
|
29473944 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate whether HAART induces vascular dysfunction in obesity and to explore the underlying mechanisms of PPARα/γ stimulation, male Wistar rats were placed on a high-calorie diet for 16 weeks.
|
31284000 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, this study aimed to determine whether ascorbic acid can inhibit obesity and nonalcoholic fatty liver disease (NAFLD) in part through the actions of PPARα.
|
30283077 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced DNA methylation is associated with enhanced induction of hepatic FGF21 expression after PPARα activation, which may partly explain the attenuation of diet-induced obesity in adulthood.
|
29434210 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, understanding the ties between PPAR- γand Wnt signaling in MSC differentiation has significant implications in diverse areas of human health, from obesity to osteoporosis to regenerative medicine.
|
29034841 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fatty acid administration, and PPARα and PPARδ (PPARα/δ) agonists, mimicked obesity and inhibited mechanistic target of rapamycin (mTOR)-mediated glycolysis.
|
30420624 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the enhanced expression of obesity-related proteins (PPAR[Formula: see text], C/EBP[Formula: see text], SREBP-1c, and FAS) in MDI medium-cultivated 3T3-L1 cells was significantly attenuated by the addition of cinnamyl alcohol at 5[Formula: see text][Formula: see text]g/mL and 10[Formula: see text][Formula: see text]g/mL.
|
28490236 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is concluded that combined DHA-T<sub>3</sub> supplementation achieves synergistic effects on liver PPARα-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders.
|
28990606 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth: A cross-sectional study according the parental characteristics and newborn's risk for child obesity (the newborns obesity's risk) NOR study.
|
27442659 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor (PPAR) gene plays an important role in obesity and PPAR δ protein is a potent inhibitor; however, few previous studies have focused on this gene.
|
26073637 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population.
|
24599720 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate the differences in the expression of PPARα target genes in human peripheral blood mononuclear cells (PBMCs) and free fatty acids (FFA) in obese and non-obese individuals after 24 h of fasting.
|
25500634 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity.
|
25502405 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism.
|
25837920 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia.
|
26673968 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5).
|
24814977 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.
|
23545576 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that Amerindians do not have association of PPAR-γ2 Ala12 and obesity; the latter was measured by waist circumference values after taken specific Amerindian normal waist parameters.
|
23096090 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These associations showed that high expression levels of CPT1A, SLC27A2, INSR, FASN, or PPARα may be indicative of a lower risk for the insulin-resistant or dyslipidemic state associated with obesity, whereas low LEPR mRNA levels appear as a marker of high low-density lipoprotein cholesterol, independently of body mass index.
|
22278432 |
2012 |