Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) inherited as one of two common haplotypes at the transmembrane protein 106B (TMEM106B) locus are associated with the risk of multiple neurodegenerative diseases, including frontotemporal lobar degeneration with pathological inclusions of TDP-43. 29970152 2018
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 AlteredExpression disease BEFREE To mimic elevated levels of TMEM106B in frontotemporal lobar degeneration (FTLD) cases, we generated transgenic mice expressing TMEM106B under the neuronal specific promoter, CamKII. 28126008 2017
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Transmembrane Protein 106B SNP rs1990622 was recently shown to modify the risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTD-TDP). 25096617 2015
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Transmembrane protein 106B (TMEM106B) has been identified as a risk factor for frontotemporal lobar degeneration, which is the second most common form of progressive dementia in people under 65 years of age. 26651479 2015
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 Biomarker disease BEFREE Our data add to the growing list of proteins that undergo intramembrane proteolysis and may shed light on the regulation of the frontotemporal lobar degeneration risk factor TMEM106B. 24872421 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions. 25085782 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE In contrast, the HpScl groups (HpScl and HpScl-AD) were more likely to exhibit genetic variants in GRN and TMEM106B that are associated with frontotemporal lobar degeneration. 24899141 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE It has been demonstrated that the TMEM106B polymorphism is associated with GRN-related frontotemporal dementia and affects age at onset in GRN mutation carriers. 24343233 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 Biomarker disease BEFREE TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. 24442578 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. 24166182 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE We investigated the rs1990622 polymorphism in relation to regional brain volumes to identify potential structures through which TMEM106B confers risk for frontotemporal lobar degeneration. 24731779 2014
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 AlteredExpression disease BEFREE Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. 24252750 2013
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. 22511793 2012
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 Biomarker disease BEFREE TMEM106B a novel risk factor for frontotemporal lobar degeneration. 21614538 2011
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 Biomarker disease BEFREE TMEM106B has recently been identified as a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). 21104415 2011
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) in a recent genome-wide association. 21220649 2011
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.100 GeneticVariation disease BEFREE Homozygous carriers of the TMEM106B protective alleles had a 50% reduced risk of developing frontotemporal lobar degeneration. 21354975 2011