Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.230 Biomarker disease MGD
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 AlteredExpression disease BEFREE PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. 10555149 1999
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 AlteredExpression disease BEFREE Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. 11087869 2000
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.100 AlteredExpression disease BEFREE Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. 11087869 2000
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE In view of the association of PPARbeta with colon cancer and increased mRNA levels of PPARbeta in colon tumours we sought in this study to examine the expression of PPARbeta in human breast epithelial cells of tumorigenic (MCF-7 and MDA-MB-231) and non-tumorigenic origin (MCF-10A). 12009300 2002
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE However, the dynamic changes in PPARbeta mRNA expression and the ability of PPARbeta in the MCF-7 cells to respond to ligand indicates that PPARbeta may play a role in mammary gland carcinogenesis through activation of downstream genes via endogenous fatty acid ligands or exogenous agonists. 12009300 2002
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.100 Biomarker disease BEFREE In view of the association of PPARbeta with colon cancer and increased mRNA levels of PPARbeta in colon tumours we sought in this study to examine the expression of PPARbeta in human breast epithelial cells of tumorigenic (MCF-7 and MDA-MB-231) and non-tumorigenic origin (MCF-10A). 12009300 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 AlteredExpression disease BEFREE Our results suggest that unlike colon cancer, PPARbeta overexpression is not an inherent property of breast cancer cell lines. 12009300 2002
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 AlteredExpression disease BEFREE Our results suggest that unlike colon cancer, PPARbeta overexpression is not an inherent property of breast cancer cell lines. 12009300 2002
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.030 AlteredExpression group BEFREE In view of the association of PPARbeta with colon cancer and increased mRNA levels of PPARbeta in colon tumours we sought in this study to examine the expression of PPARbeta in human breast epithelial cells of tumorigenic (MCF-7 and MDA-MB-231) and non-tumorigenic origin (MCF-10A). 12009300 2002
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 AlteredExpression group LHGDN Peroxisome proliferator-activated receptor beta expression in human breast epithelial cell lines of tumorigenic and non-tumorigenic origin. 12009300 2002
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 AlteredExpression disease LHGDN Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells. 11980898 2002
CUI: C1153706
Disease: Endometrial adenocarcinoma
Endometrial adenocarcinoma 		0.010 AlteredExpression disease BEFREE Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. 11228540 2002
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.060 GeneticVariation disease BEFREE Plasma lipoprotein concentrations and risk of CHD according to PPARD genotype. 14641801 2003
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.060 GeneticVariation disease BEFREE Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. 14641801 2003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.050 GeneticVariation disease BEFREE Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. 14641801 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.010 AlteredExpression group LHGDN The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. 12909723 2003
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.010 Biomarker disease BEFREE Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. 13130515 2003
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE The results of recent studies using selective agonists for peroxisome proliferator-activated receptor beta (PPARbeta) suggest that this receptor may have a role in regulating levels of serum lipids in animal models of obesity and insulin resistance. 15001574 2004
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE The nuclear receptor peroxisome proliferator-activated receptor delta [PPARdelta/beta (NR1C2)] has been implicated in colorectal carcinogenesis by various molecular genetic observations. 15126355 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.060 Biomarker disease BEFREE Together, these results indicate a clear role for PPARbeta in regulating levels of serum triglycerides in mice on a high fat Western diet by modulating both VLDL production and LPL-mediated catabolism of VLDL-triglycerides and also suggest a potential therapeutic role for PPARbeta in the improvement of serum lipids in the setting of metabolic syndrome. 15001574 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.040 Biomarker disease BEFREE Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. 15126355 2004
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.040 Biomarker disease BEFREE Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. 15126355 2004
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker phenotype RGD Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. 15728586 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Therapeutic disease CTD_human Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. 16168052 2005