Disease: Huntington Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.230 Biomarker disease BEFREE PPARδ directly involves in the pathogenesis of HD and treatment with a brain-permeable PPARδ-agonist (KD3010) alleviates its severity in mice. 31625071 2020
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.230 Biomarker disease BEFREE To determine the basis for PPARδ neuroprotection, we evaluated metabolic function and noted markedly impaired oxidative metabolism in HD neurons, which was rescued by bexarotene or KD3010. 29212711 2017
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.230 Biomarker disease BEFREE PPAR-δ activation also reduced HTT-induced neurotoxicity in vitro and in medium spiny-like neurons generated from stem cells derived from individuals with HD, indicating that PPAR-δ activation may be beneficial in HD and related disorders. 26642438 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.230 Biomarker disease MGD