|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma C161-->T polymorphism and coronary artery disease.
|
10690291 |
1999 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PPARgamma-2 genotype was not associated with an increased or reduced risk of the occurrence of CHD and can therefore not be regarded as an independent risk factor for CHD in patients with diabetes mellitus.
|
11916624 |
2002 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A genetic polymorphism (C161T) at exon 6 of PPAR gamma gene (PPARG) was reported to be associated with the onset of coronary artery disease.
|
14616762 |
2003 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene-gene interaction of PPARgamma and ApoE affects coronary heart disease risk.
|
14659862 |
2003 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Samples from CHD patients showed a higher expression of PPARgamma in all of the samples compared to those from CMP patients (aorta: 1.99-fold; coronary arteries: 1.35; left ventricles: 1.23).
|
14675851 |
2003 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the relationship between PPARG2 P12A and CHD risk in women (Nurses' Health Study) and men (Health Professionals Follow-Up Study) in nested case control settings.
|
15920035 |
2005 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women.
|
15920035 |
2005 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association of Pro12Ala polymorphism of PPAR-gamma gene with coronary artery disease in Korean subjects.
|
17322631 |
2007 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PPARgamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression.
|
17892998 |
2007 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim was to investigate if the polymorphism PPARgamma2 Pro12Ala, which encodes a less efficient transcription factor, was associated with risk of acute coronary disease and if there were interactions between this polymorphism and factors that modify PPARgamma activity, such as alcohol intake, smoking, and use of non-steroidal anti-inflammatory medicine.
|
19500413 |
2009 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that one SNP of the PPARG genotype accounted for a significant portion of the total body weight reduction variance in response to a short-term intervention consisting of calorie restriction; however, no relationship was found between these SNPs and the changes in CHD risk factors which accompanied weight loss.
|
19543210 |
2009 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus.
|
20334678 |
2010 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Associations for lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in an Indian population.
|
20430250 |
2010 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus ADRB2 and GPR74 genes are associated with adipocyte lipolysis, GPR74 also with BMI; PPARG and SREBP1, which promote adipogenesis and lipid storage, are associated with T2D and possible adiposity; ADIPOQ and ARL15 are associated with circulating levels of adiponectin, ARL15 also with coronary heart disease.
|
21036322 |
2010 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood.
|
21548985 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between C1431T polymorphism in peroxisome proliferator-activated receptor-γ gene and coronary artery disease in Chinese Han population.
|
21643757 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We suggested that homozygote CC genotype of the PPARγ C161T polymorphism might be associated with an increased CHD risk especially in patients with diabetes.
|
21833536 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations of receptor for advanced glycation end products -374 T/A and Gly82 Ser and peroxisome proliferator-activated receptor gamma Pro12Ala polymorphisms in Turkish coronary artery disease patients.
|
21861709 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population.
|
22515931 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty studies testing the association between PPARG gene polymorphisms and CHD were examined: 12 studies of P12A; 8 studies of C161T.
|
22987045 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the Pro12Ala, C161T and C1431T polymorphisms of PPARG gene are not associated with CHD susceptibility.
|
23065280 |
2013 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis.
|
23266668 |
2013 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma-2 gene (PPARγ2) is associated with increased risk of coronary artery disease: a meta-analysis.
|
23300871 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increasing effect of the PPARA-V162 allele on serum TC and LDL-C levels was weakened with the presence of PPARG-161T allele in the non-diabetic CHD patients.
|
23583468 |
2013 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ.
|
25595457 |
2015 |