|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet.
|
22102511 |
2011 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs.
|
30420515 |
2018 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity.
|
24969838 |
2014 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.
|
9753710 |
1998 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR.
|
15860437 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk.
|
12395215 |
2002 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity.
|
19913841 |
2010 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome.
|
21643757 |
2012 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association.
|
22410809 |
2012 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity.
|
15972940 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034).
|
24200052 |
2014 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests that the PPARG gene has a gender-specific effect and contributes to the susceptibility to obesity in this population.
|
17653445 |
2007 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma is an important regulator of adiposity in mouse and man, and common variation in the PPARG gene has been associated with birthweight, adult obesity, insulin sensitivity and type 2 diabetes.
|
16007414 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women.
|
11916956 |
2002 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population.
|
16108843 |
2005 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The rs1801282;rs1805192" genes_norm="5468">Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity.
|
18280041 |
2008 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Potential interactions between prenatal DHA and the peroxisome proliferator-activated receptor-γ (PPARγ) genotype as a measure of the genetic predisposition to obesity were investigated.
|
27030533 |
2016 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the PPARgamma gene are unlikely to be major contributors to HAIRAN syndrome with obesity.
|
10762291 |
2000 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In 1708 women of the EDEN mother-child cohort, the PPARγ Pro12Ala and C1431T polymorphisms were genotyped and analyzed in association with maternal prepregnancy body mass index, obesity before pregnancy, and gestational diabetes, separately and also combined in haplotypes.
|
21795447 |
2011 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that targeted PPARγ mutations resulting in constitutive deacetylation (K268R/K293R, 2KR) increased energy expenditure and protected from visceral adiposity and diet-induced obesity by augmenting brown remodeling of white adipose tissues.
|
29589839 |
2018 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population.
|
19733160 |
2009 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m2) nondiabetic subjects.
|
16231017 |
2006 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
Obesity
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005).
|
16029943 |
2005 |