Congestive heart failure
|
0.480 |
AlteredExpression
|
disease |
BEFREE |
PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1alpha) is a type of transcriptional coactivator that predominantly resides in the nucleus and is downregulated during heart failure.
|
31133853 |
2019 |
Congestive heart failure
|
0.480 |
AlteredExpression
|
disease |
BEFREE |
Our results highlight the interaction of Yulink with PPARγ in regulating Serca2 expression and suggest a mechanistic role of the Yulink in the development of human heart failure and SCD.-Tsai, C.-T., Kuo, M.-W., Lin, J.-L., Yu, A. L., Yu, J.
|
29401584 |
2018 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema, weight gain, and heart failure.
|
29081262 |
2018 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
The treatment of type 2 diabetes with full peroxisome proliferator-activated receptor gamma (PPARγ) agonists improves insulin sensitivity, but is associated with weight gain, heart failure, peripheral oedema and bone loss.
|
27631136 |
2017 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
Activation of PPARγ pathway has been shown to enhance fatty acid oxidation, improve endothelial cell function, and decrease myocardial fibrosis in heart failure.
|
27937122 |
2017 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
CTD_human |
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
|
26670611 |
2016 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator activated receptor-γ agonists present angiogenic activity in vitro; however, systemic administration of peroxisome proliferator-activated receptor-γ agonists is hampered by its side effects, including heart failure.
|
22879581 |
2012 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
Here we report that congestive heart failure is associated with a significant decrease of myocardial estrogen-related receptor-α (ERRα), but not peroxisome proliferator-activated receptor-γ coactivator 1α, in human heart failure samples.
|
21825219 |
2011 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
BEFREE |
Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle.
|
19300450 |
2009 |
Congestive heart failure
|
0.480 |
Biomarker
|
disease |
HPO |
|
|
|