Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists.
|
30931956 |
2019 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, FPLD3-associated PPARγ mutations consistently cause intra- and/or intermolecular defects; colon cancer-associated PPARγ mutations on the other hand may play a role in colon cancer onset and progression, but this is not due to their effects on the most well-studied functional characteristics of PPARγ.
|
30595551 |
2019 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, dihydroartemisinin inhibits colon cancer growth by inducing apoptosis and increasing the expression of PPARγ.
|
29472793 |
2018 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Comparison of the transcriptome data of metastasis-competent CTC-MCC-41 cells and of HT-29 cells (derived from a primary colon cancer) highlights the differential expression of genes that regulate energy metabolism [peroxisome proliferator-activated receptor γ coactivator 1A (<i>PPARGC1A</i>), peroxisome proliferator-activated receptor γ coactivator 1B (<i>PPARGC1B</i>), fatty acid binding protein 1 (<i>FABP1</i>), aldehyde dehydrogenase 3 family member A1 (<i>ALDH3A1</i>)], DNA repair [BRCA1 interacting protein C-terminal helicase 1 (<i>BRIP1</i>), Fanconi anemia complementation group B (<i>FANCB</i>), Fanconi anemia complementation group M (<i>FANCM</i>)], and stemness [glutaminase 2 (<i>GLS2</i>), cystathionine-beta-synthase (<i>CBS</i>), and cystathionine gamma-lyase (<i>CTH</i>)].
|
28007957 |
2017 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer.
|
28298922 |
2017 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transient exposure to CDDP and induction of the CDDP resistance decreased expression of peroxisome proliferator-activated receptor-γ (PPARγ) in MKN45 and colon cancer LoVo cells.
|
27417252 |
2016 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also correlated EZR and PPARγ expression in our series of CRC specimens and the expression profiling of all five proteins levels in the publicly available colon cancer genomic data from Oncomine and Cancer Genome Atlas (TCGA) colon adenocarcinoma (COAD) datasets.
|
27499265 |
2016 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, at our knowledge, our results are the first to show that the reduction of PPARγ levels contributes to WIN-induced colon carcinoma cell death by blocking the pro-survival autophagic response of cells.
|
24696378 |
2014 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, in current study, ceramide, COX-2, 15-deoxy prostaglandin J2(15-deoxy PGJ2), PPAR γ , and β -catenin were estimated to evaluate the effect of fish oil on lipid mediated and Wnt/ β -catenin signaling in colon carcinoma.
|
24999478 |
2014 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the relationship between PSF and PPARγ in colon cancer, we evaluated the effects of PSF expression in DLD-1 and HT-29 colon cancer cell lines, which express low and high levels of PPARγ, respectively PSF affected the ability of PPARγ to bind, and expression of PSF siRNA significantly suppressed the proliferation of colon cancer cells.
|
23516550 |
2013 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, SOX9, β-catenin and PPARγ expression levels are deregulated in the CRC tissue, and in colon cancer cell lines ligand-dependent PPARγ activation unevenly influences SOX9 and β-catenin expression and subcellular localization, suggesting a variable mechanistic role in colon carcinogenesis.
|
23583560 |
2013 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This suggests that PPARγ expression may be an important factor for cell growth regulation in colon cancer.
|
22771328 |
2012 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Stratified meta-analysis indicated that PPAR-gamma 34 C>G was associated with colon cancer (OR = 0.8, 95% CI: 0.65-0.99, P = 0.04) in random-effect model, and the G allele decreased colon cancer risk.
|
20440859 |
2010 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPARgamma ligands as ciglitazone and pioglitazone, on two colon cancer cell lines: HCA-7 and HCT-116.
|
20510503 |
2010 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We observed a marked synergism between peroxisome proliferator-activated receptor gamma (PPARgamma) ligands and X-linked inhibitor of apoptosis (XIAP) down-regulation in colon cancer.
|
18704457 |
2009 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines.
|
19551868 |
2009 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
For in vivo studies, 1,2-dimethylhydrazine dihydrochloride (DMH) was s.c. injected to induce colon cancer in PPARgamma(+/+) and PPARgamma(+/-) mice.
|
19458067 |
2009 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, EPA suppressed HT-29 cell growth and this effect was significantly reversed by the addition of GW, suggesting that in part the physiological actions of EPA are the result of PPARgamma activation.
|
18203887 |
2008 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that PPARgamma plays a role as a physiological regulator of colonic epithelial cell turnover and consequently predisposition to the development of colon cancer in early stage.
|
18391483 |
2008 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of this protein may prevent PPARgamma ligand efficiency in colon cancer treatment.
|
17611675 |
2007 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To elucidate cdk5's role in PPARgamma ligand-induced antiproliferation of colon cancer cells, HT-29 cells were treated with ciglitazone.
|
16327995 |
2006 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Based on our findings, p38 MAPK and transcription factor PPARgamma can be considered as molecular targets of resveratrol in the regulation of cell proliferation and SSAT activity, respectively, in a cell culture model of colon cancer.
|
16849586 |
2006 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was a significant interaction between the -200A>C IGFBP3 polymorphism and the Pro12Ala PPARgamma polymorphism and risk of colon cancer (p for interaction = 0.02) with individuals being at significantly lower risk if they had both the CC IGFBP3 genotype and the PA/AA PPARgamma genotype.
|
16489531 |
2006 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
High lutein intake [odds ratio (OR), 0.63; 95% confidence interval (95% CI), 0.44-0.89], low refined grain intake (OR, 0.70; 95% CI, 0.53-0.94), or a high prudent diet score (OR, 0.66; 95% CI, 0.49-0.89) and PA/AA PPARgamma genotype were associated with reduced colon cancer risk.
|
15894676 |
2005 |
Colon Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, PPARgamma protein levels are elevated, possibly through sequestration by activated beta-catenin in colon cancer cell lines.
|
15665104 |
2005 |