Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.340 GeneticVariation disease BEFREE This retrospective study aims at evaluating the frequency and impact of TET2 mutations in 247 secondary acute myeloid leukemia cases referred to as myelodysplasia-related changes (n=201) or therapy-related (n=46) leukemias. 21508122 2011
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.340 GeneticVariation disease BEFREE Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes including chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML) and secondary AML (sAML). 21057493 2010
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.340 Biomarker disease BEFREE The incidence of TET2, ASXL1, CBL, IDH or IKZF1 mutations in these disorders ranges from 0 to 17%; these latter mutations are more common in chronic (TET2, ASXL1, CBL) or juvenile (CBL) myelomonocytic leukemias, mastocytosis (TET2), myelodysplastic syndromes (TET2, ASXL1) and secondary acute myeloid leukemia, including blast-phase MPN (IDH, ASXL1, IKZF1). 20428194 2010
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.340 GeneticVariation disease BEFREE TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (19%), in 24 of 198 patients with myeloproliferative disorders (12%) (with or without the JAK2 V617F mutation), in 5 of 21 patients with secondary AML (24%), and in 2 of 9 patients with chronic myelomonocytic leukemia (22%). 19474426 2009
CUI: C0280449
Disease: secondary acute myeloid leukemia
secondary acute myeloid leukemia
0.340 GeneticVariation disease UNIPROT