|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Newly discovered uterine sarcoma subtypes include high-grade endometrial stromal sarcomas with BCOR genetic abnormalities, fibrosarcoma-like uterine sarcomas with NTRK rearrangements and COL1A-PDGFRB fusions, as well as undifferentiated uterine sarcomas with SMARCA4 mutations.
|
31846533 |
2020 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCOR-ITDs define a rare subset of pediatric sarcomas and clinically aggressive endometrial stromal sarcoma cases, as defined by NGS for the first time.
|
30380541 |
2019 |
|
Endometrial Stromal Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This report supports emerging evidence that ESS with ZC3H7B-BCOR gene fusion may have an aggressive clinical course in spite of its low-grade histology.
|
29901520 |
2019 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumors with YWHAE-NUTM2 fusions and BCOR genetic abnormalities showed morphology characteristic of high-grade endometrial stromal sarcomas.
|
30789359 |
2019 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumors with ZC3H7B-BCOR fusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology.
|
29192652 |
2018 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we describe two novel EPC1 fusion genes in endometrial stromal sarcoma: EPC1-SUZ12 and EPC1-BCOR.
|
30144186 |
2018 |
|
Endometrial Stromal Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCOR ITD were present in 1 uterine sarcoma diagnosed as HG-ESS and 2 undifferentiated sarcomas with uniform nuclear features, all of which lacked any of the recurrent chromosome translocations known to occur in ESS.
|
29200103 |
2018 |
|
Endometrial Stromal Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It also describes the recent characterisation of endometrial stromal sarcoma with t(X;22)(p11;q13) resulting in ZC3H7B-BCOR fusion, a noteworthy entity due to its close histological resemblance to myxoid leiomyosarcoma.
|
29275929 |
2018 |
|
Endometrial Stromal Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of the review of these cases, we find that ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade ESS and shares significant morphologic overlap with myxoid leiomyosarcoma.
|
27631520 |
2017 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCOR staining was weakly positive in <5% of tumor cells in 4 of 66 (6%) low-grade endometrial stromal sarcomas and 1 of 18 (6%) endometrial stromal nodules and weakly to moderately positive in <5-40% of tumor cells in 6 of 31 (19%) leiomyosarcomas.
|
28621321 |
2017 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
More recently, previously under-recognized lesions have been identified, in part due to our growing knowledge of their underlying molecular alterations: uterine inflammatory myofibroblastic tumor frequently harbors ALK rearrangements and a novel ZC3H7B-BCOR gene fusion has been described in a subset of myxoid high-grade endometrial stromal sarcomas.
|
28787279 |
2017 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6.
|
24530230 |
2014 |
|
Endometrial Stromal Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether or not the (patho)genetic subsets JAZF1-SUZ12, PHF1 rearrangements, and ZC3H7B-BCOR correspond to any phenotypic, let alone clinically important, differences in ESS remain unknown.
|
23580382 |
2013 |