RNF43, ring finger protein 43, 54894

N. diseases: 88; N. variants: 9
Disease: Pancreatic Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.330 GeneticVariation disease BEFREE Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. 29117169 2017
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.330 GeneticVariation disease BEFREE Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. 27869803 2017
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.330 GeneticVariation disease BEFREE Ubiquitin E3 ligase ring finger 43 (RNF43) has been suggested as a negative regulator of Wnt signaling, and mutations of RNF43 have been identified in various tumors, including cystic pancreatic tumors. 23847203 2013
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.330 CausalMutation disease CGI