|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
|
28112199 |
2017 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
|
27363682 |
2016 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
|
26007630 |
2015 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
|
23502783 |
2013 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
|
23955597 |
2013 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
|
23502783 |
2013 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)).
|
22120009 |
2011 |
|
Multiple Myeloma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)).
|
22120009 |
2011 |
|
Multiple Myeloma
|
0.400 |
Biomarker
|
disease |
CTD_human |
We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)).
|
22120009 |
2011 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
However, recently, deletions in ULK4 have been genetically linked to increased susceptibility to developing schizophrenia, a devastating neuropsychiatric disease with high heritability but few genes identified.
|
31841327 |
2020 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine/Threonine kinase have been reported in approximately 1/1000 of patients suffering pleiotropic clinical conditions of schizophrenia, depression, autistic spectrum disorder (ASD), developmental delay, language delay, intellectual disability, or behavioral disorder.
|
29391390 |
2018 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
ULK4 modulates multiple signalling pathways that include ERK, p38, PKC and JNK, which are involved in stress responses and implicated in schizophrenia.
|
24284070 |
2014 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
ULK4 modulates multiple signalling pathways that include ERK, p38, PKC and JNK, which are involved in stress responses and implicated in schizophrenia.
|
24284070 |
2014 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Deletions removing exons 33 and 34 of the large splice variant of ULK4 also were enriched in Icelandic schizophrenia and bipolar patients compared with 98,022 controls (P = 0.0007 for schizophrenia plus bipolar disorder).
|
24284070 |
2014 |
|
Hydrocephalus
|
0.200 |
Biomarker
|
disease |
MGD |
Congenital hydrocephalus in genetically engineered mice.
|
21746835 |
2012 |
|
Hypertensive disease
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
|
28498854 |
2017 |
|
Hypertensive disease
|
0.110 |
Biomarker
|
group |
BEFREE |
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
|
19430479 |
2009 |
|
Monoclonal Gammopathy of Undetermined Significance
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma.
|
30737484 |
2019 |
|
Paraproteinemias
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma.
|
30737484 |
2019 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
|
29912962 |
2018 |