Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously discovered that deletion of cell cycle inhibitors p16<sup>Ink4a</sup> (p16) or p18<sup>Ink4c</sup> (p18) is required for development of Brca1-deficient basal-like mammary tumors, and that mice lacking p18 develop luminal-type mammary tumors.
|
29996906 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumour growth assays demonstrated the P18 peptide suppressed angiogenesis of HCC in vivo.
|
28627623 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Next, we hypothesized that HULC might function through regulating a tumor suppressor gene p18 located near HULC in the same chromosome.
|
22685290 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To examine the function of p18 as a putative tumor suppressor in myeloma cells, a zinc-inducible p18 construct was stably transfected into KMS12, a MM cell line with biallelic p18 and monoallelic p16 deletions as well as cyclin D1 overexpression.
|
11840272 |
2002 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HLF, which was deficient in the protein product of the retinoblastoma tumor-suppressor gene (pRb), responded most profoundly to troglitazone, showing an increased expression in not only p21, but also in p27 and in p18.
|
11343236 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By virtue of its structural and functional similarities with the p16 gene, p18 has been implicated as a tumour suppressor gene in a variety of cancers.
|
10736068 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CDKN2C gene coding for the cyclin-dependent kinase inhibitor p18 is localized on 1p32, a region frequently involved in chromosomal changes in melanomas and other tumors.
|
9724087 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin-dependent kinase inhibitors known as p15, p16, p18 and p19 have been suggested as candidates for tumor suppressor genes.
|
9639410 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that p18 inactivation by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors.
|
8840966 |
1996 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The p15(INK4B), p16(INK4) and p18 genes are members of the gene family coding for inhibitors of cyclin-dependent kinases 4 and 6. p15(INK4B) and p16(INK4) are located at 9p21, a chromosomal region frequently deleted in many human neoplasms.
|
8631583 |
1996 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
With the exception of one breast cancer cell line, no deletions or mutations were found in the p18 gene in either cultured cell lines or primary tumors.
|
8570224 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results do not support a role for p18 in the pathogenesis of the lymphoid neoplasms studied.
|
8637248 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin-dependent kinase inhibitors known as p15, p16 and p18 have been suggested as candidates for tumour suppressor genes.
|
7577621 |
1995 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we examined the contribution of the cell cycle inhibitor genes P15, P16, and P18 to pathogenesis in a large panel of 209 cytogenetically characterized B-cell NHL tumors representing varied histologic groups.
|
7579381 |
1995 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The questions arise if high level p18 expression in certain malignancies may play a primary role in driving cell proliferation or, based on chromosomal localization and inactivation of p18 expression in one lymphoma, if p18 may act as a tumor suppressor.
|
8397372 |
1993 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high levels of expression of p18 in brain and neuroendocrine tumor cells, its possible role in growth regulation, and its chromosomal location in a region frequently deleted in neuroectodermal tumors suggest that this gene may be involved in common genetic events occurring in these tumors.
|
2278968 |
1990 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These studies demonstrate that host p18 imposes the requirement for the viral cyclin to reactivate from latency by functioning in latently infected cells and that p18 expression is associated with decreased disease, thereby identifying p18 as a compelling host target to limit chronic gammaherpesvirus pathogenesis.<b>IMPORTANCE</b> Gammaherpesviruses are ubiquitous viruses associated with multiple malignancies.
|
29298882 |
2018 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.
|
21087931 |
2011 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
To determine the molecular basis for the inhibitory function of p18, we introduced 11 missense mutations of conserved residues that were identified in p16 of cancer cell lines into p18.
|
9973200 |
1999 |
Malignant Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Absence of p18 mutations or deletions in lymphoid malignancies.
|
8637248 |
1996 |
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The questions arise if high level p18 expression in certain malignancies may play a primary role in driving cell proliferation or, based on chromosomal localization and inactivation of p18 expression in one lymphoma, if p18 may act as a tumor suppressor.
|
8397372 |
1993 |
Carcinogenesis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the p18 gene were not a major factor in medullary thyroid carcinoma tumorigenesis.
|
20878247 |
2011 |
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our data strongly indicate that oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of MTC.
|
18316595 |
2008 |
leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells.
|
9639410 |
1998 |
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
To examine the involvement of p18 in parathyroid tumorigenesis, we analyzed 25 parathyroid adenomas for mutations of the p18 coding exons by single strand conformational polymorphism analysis and sequencing.
|
9286748 |
1997 |