|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously discovered that deletion of cell cycle inhibitors p16<sup>Ink4a</sup> (p16) or p18<sup>Ink4c</sup> (p18) is required for development of Brca1-deficient basal-like mammary tumors, and that mice lacking p18 develop luminal-type mammary tumors.
|
29996906 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumour growth assays demonstrated the P18 peptide suppressed angiogenesis of HCC in vivo.
|
28627623 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Next, we hypothesized that HULC might function through regulating a tumor suppressor gene p18 located near HULC in the same chromosome.
|
22685290 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To examine the function of p18 as a putative tumor suppressor in myeloma cells, a zinc-inducible p18 construct was stably transfected into KMS12, a MM cell line with biallelic p18 and monoallelic p16 deletions as well as cyclin D1 overexpression.
|
11840272 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HLF, which was deficient in the protein product of the retinoblastoma tumor-suppressor gene (pRb), responded most profoundly to troglitazone, showing an increased expression in not only p21, but also in p27 and in p18.
|
11343236 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By virtue of its structural and functional similarities with the p16 gene, p18 has been implicated as a tumour suppressor gene in a variety of cancers.
|
10736068 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CDKN2C gene coding for the cyclin-dependent kinase inhibitor p18 is localized on 1p32, a region frequently involved in chromosomal changes in melanomas and other tumors.
|
9724087 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin-dependent kinase inhibitors known as p15, p16, p18 and p19 have been suggested as candidates for tumor suppressor genes.
|
9639410 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that p18 inactivation by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors.
|
8840966 |
1996 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The p15(INK4B), p16(INK4) and p18 genes are members of the gene family coding for inhibitors of cyclin-dependent kinases 4 and 6. p15(INK4B) and p16(INK4) are located at 9p21, a chromosomal region frequently deleted in many human neoplasms.
|
8631583 |
1996 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
With the exception of one breast cancer cell line, no deletions or mutations were found in the p18 gene in either cultured cell lines or primary tumors.
|
8570224 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results do not support a role for p18 in the pathogenesis of the lymphoid neoplasms studied.
|
8637248 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclin-dependent kinase inhibitors known as p15, p16 and p18 have been suggested as candidates for tumour suppressor genes.
|
7577621 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we examined the contribution of the cell cycle inhibitor genes P15, P16, and P18 to pathogenesis in a large panel of 209 cytogenetically characterized B-cell NHL tumors representing varied histologic groups.
|
7579381 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The questions arise if high level p18 expression in certain malignancies may play a primary role in driving cell proliferation or, based on chromosomal localization and inactivation of p18 expression in one lymphoma, if p18 may act as a tumor suppressor.
|
8397372 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high levels of expression of p18 in brain and neuroendocrine tumor cells, its possible role in growth regulation, and its chromosomal location in a region frequently deleted in neuroectodermal tumors suggest that this gene may be involved in common genetic events occurring in these tumors.
|
2278968 |
1990 |