Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Biomarker disease BEFREE Aim of our study was to assess the effects of adeno-associated virus serotype 9 (AAV9) - mediated cardiac-specific expression of constitutively active inhibitor-1 (I-1c) and to investigate whether I-1c is able to attenuate the development of heart failure in mice subjected to transverse aortic constriction (TAC). 29350681 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 AlteredExpression disease BEFREE The protein phosphatase-1 activity was lower in the 20 mg/kg astragalosides group than in the CHF group (0.22 vs 0.44, P < 0.01), and the inhibitor-1 levels in the astragalosides and captopril-treated groups were increased. 29710499 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Biomarker disease BEFREE This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated viral vector carrying I-1c (BNP116.I-1c) in a preclinical model of nonischemic HF, and to assess thoroughly the safety of BNP116.I-1c gene therapy. 28958332 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 GeneticVariation disease BEFREE We recently identified a novel human polymorphism (G109E) in the inhibitor-1 gene with a frequency of 7% in either normal or heart failure patients. 26455482 2015
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 AlteredExpression disease BEFREE In summary, I-1c overexpression using BNP116 improves cardiac function in a clinically relevant model of ischemic HF. 25023328 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Biomarker disease BEFREE The aim of this study was to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer on cardiac function in a porcine model of heart failure induced by myocardial infarction. 23271792 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Biomarker disease BEFREE Consequently, the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models. 21354993 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Therapeutic disease CTD_human Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. 20071777 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 GeneticVariation disease BEFREE The present findings indicate that the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development. 18698139 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.390 Biomarker disease BEFREE I-1 was >500-fold enriched from left ventricular myocardium (LVM) from patients with terminal HF (n=16) and non-failing controls (NF, n=5) and quantified with an affinity-purified I-1 and a I-1 phosphospecific antiserum. 14732205 2004