Congestive heart failure
|
0.390 |
Biomarker
|
disease |
BEFREE |
Aim of our study was to assess the effects of adeno-associated virus serotype 9 (AAV9) - mediated cardiac-specific expression of constitutively active inhibitor-1 (I-1c) and to investigate whether I-1c is able to attenuate the development of heart failure in mice subjected to transverse aortic constriction (TAC).
|
29350681 |
2018 |
Congestive heart failure
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The protein phosphatase-1 activity was lower in the 20 mg/kg astragalosides group than in the CHF group (0.22 vs 0.44, P < 0.01), and the inhibitor-1 levels in the astragalosides and captopril-treated groups were increased.
|
29710499 |
2018 |
Congestive heart failure
|
0.390 |
Biomarker
|
disease |
BEFREE |
This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated viral vector carrying I-1c (BNP116.I-1c) in a preclinical model of nonischemic HF, and to assess thoroughly the safety of BNP116.I-1c gene therapy.
|
28958332 |
2017 |
Congestive heart failure
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We recently identified a novel human polymorphism (G109E) in the inhibitor-1 gene with a frequency of 7% in either normal or heart failure patients.
|
26455482 |
2015 |
Congestive heart failure
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
In summary, I-1c overexpression using BNP116 improves cardiac function in a clinically relevant model of ischemic HF.
|
25023328 |
2014 |
Congestive heart failure
|
0.390 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer on cardiac function in a porcine model of heart failure induced by myocardial infarction.
|
23271792 |
2013 |
Congestive heart failure
|
0.390 |
Biomarker
|
disease |
BEFREE |
Consequently, the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models.
|
21354993 |
2011 |
Congestive heart failure
|
0.390 |
Therapeutic
|
disease |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |
Congestive heart failure
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The present findings indicate that the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development.
|
18698139 |
2009 |
Congestive heart failure
|
0.390 |
Biomarker
|
disease |
BEFREE |
I-1 was >500-fold enriched from left ventricular myocardium (LVM) from patients with terminal HF (n=16) and non-failing controls (NF, n=5) and quantified with an affinity-purified I-1 and a I-1 phosphospecific antiserum.
|
14732205 |
2004 |
Heart failure
|
0.380 |
Biomarker
|
disease |
BEFREE |
Aim of our study was to assess the effects of adeno-associated virus serotype 9 (AAV9) - mediated cardiac-specific expression of constitutively active inhibitor-1 (I-1c) and to investigate whether I-1c is able to attenuate the development of heart failure in mice subjected to transverse aortic constriction (TAC).
|
29350681 |
2018 |
Heart failure
|
0.380 |
Biomarker
|
disease |
BEFREE |
This study sought to determine the therapeutic efficacy of a re-engineered adenoassociated viral vector carrying I-1c (BNP116.I-1c) in a preclinical model of nonischemic HF, and to assess thoroughly the safety of BNP116.I-1c gene therapy.
|
28958332 |
2017 |
Heart failure
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We recently identified a novel human polymorphism (G109E) in the inhibitor-1 gene with a frequency of 7% in either normal or heart failure patients.
|
26455482 |
2015 |
Heart failure
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In summary, I-1c overexpression using BNP116 improves cardiac function in a clinically relevant model of ischemic HF.
|
25023328 |
2014 |
Heart failure
|
0.380 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the effect of activating the inhibitor (I-1c) of protein phosphatase 1 (I-1) through gene transfer on cardiac function in a porcine model of heart failure induced by myocardial infarction.
|
23271792 |
2013 |
Heart failure
|
0.380 |
Biomarker
|
disease |
BEFREE |
Consequently, the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models.
|
21354993 |
2011 |
Heart failure
|
0.380 |
Therapeutic
|
disease |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |
Heart failure
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The present findings indicate that the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development.
|
18698139 |
2009 |
Heart failure
|
0.380 |
Biomarker
|
disease |
BEFREE |
I-1 was >500-fold enriched from left ventricular myocardium (LVM) from patients with terminal HF (n=16) and non-failing controls (NF, n=5) and quantified with an affinity-purified I-1 and a I-1 phosphospecific antiserum.
|
14732205 |
2004 |
Cardiac Arrhythmia
|
0.320 |
GeneticVariation
|
phenotype |
BEFREE |
Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.
|
26455482 |
2015 |
Cardiac Arrhythmia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Consequently, the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models.
|
21354993 |
2011 |
Cardiac Arrhythmia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |
Left-Sided Heart Failure
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |
Cardiomyopathies, Primary
|
0.300 |
Biomarker
|
group |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |
Myocardial Diseases, Secondary
|
0.300 |
Biomarker
|
group |
CTD_human |
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.
|
20071777 |
2010 |