|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
<b>Abbreviations:</b> ATG16L1: autophagy-related 16-like 1 (S. cerevisiae); DAMP: damage-associated molecular pattern; HBSS: Hanks balanced salt solution; HMGB1: high mobility group box 1; IBD: inflammatory bowel disease; IL1B/Il-1β: interleukin 1 beta; IL10: interleukin 10; IL17/IL-17: interleukin 17; MEFs: mouse embryonic fibroblasts; STAT3: signal transducer and activator of transcription 3; TLR: toll-like receptor; TNF/TNF-α: tumor necrosis factor.
|
30894054 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity.
|
18671817 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Actively inflamed intestinal biopsies from CD patients carrying either ATG16L1 or PTPN2 genetic variants revealed aberrant LC3B expression patterns when compared with samples from non-IBD control patients.
|
21987459 |
2012 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
CTD_human |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.
|
19491842 |
2009 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Cells harbouring the ATG16L1 T300A allele associated with inflammatory bowel disease were also found to accumulate cholesterol and be defective in repair, linking a common inflammatory disease to plasma membrane integrity.
|
30478389 |
2018 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Furthermore, TMAO-mediated effects were observably reversed by over-expression ATG16L1 and siRNA-mediated knockdown NLRP3.The present results support the hypothesis that TMAO may be involved in the pathogenesis of IBD by impacting ATG16L1-induced autophagy and activating NLRP3 inflammasome, suggesting a potential therapeutic targets for the treatment of IBD and TMAO-associated complications.
|
28629999 |
2017 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms in the known IBD-associated gene ATG16L1 correlate with requirement of treatment, suggesting a different IBD disease phenotype in these patients.
|
29228965 |
2017 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Genome scans have robustly identified 11 susceptibility genes and loci and highlighted a number of new, previously unsuspected pathways as playing an important role in IBD pathogenesis-including the IL23 pathway in IBD overall and specific aspects of innate immunity (particularly NOD2 and the autophagy genes ATG16L1 and IRGM) in CD.
|
18753178 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genome wide screens have also identified NOD2/CARD15, IL23 receptor, and ATG16L1 variants as important in IBD susceptibility and pathogenesis.
|
18499066 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.
|
19683022 |
2009 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Loss of A20 and Atg16l1 in mouse intestinal epithelium induces spontaneous IBD-like pathology, as characterized by severe inflammation and increased intestinal epithelial cell death in both small and large intestine.
|
31015422 |
2019 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Neither the other two NOD2 variants, nor the known variants in IL23R and ATG16L1 were found to be risk factors for CD, UC or IBD.
|
20082483 |
2010 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
LHGDN |
No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
No significant association was observed between IL23R genotype or ATG16L1 genotype and IBD subphenotypes.
|
17894849 |
2007 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
North American and European genome-wide association scans have identified ATG16L1 and IL23R as novel inflammatory bowel disease (IBD) susceptibility genes and subsequent reports confirmed these findings in large independent populations.
|
18499543 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Now, experiments with Atg16L1 transgenic mice indicate multiple roles for autophagy in inflammatory bowel disease via effects on Paneth cells, a runaway inflammasome, and the proinflammatory cytokine IL-1beta.
|
19000829 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
One of those four patients was homozygous for the ATG16L1 Crohn's disease-associated gene variant but had no history of inflammatory bowel disease.
|
31692018 |
2020 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our aims were: to replicate the ATG16L1 Thr300Ala association with inflammatory bowel disease (IBD) in the Spanish population, to perform a meta-analysis to determine the risk conferred to the different IBD subgroups, and to test for the interaction with CARD15 or IL23R risk loci.
|
19575361 |
2009 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.
|
18698678 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Several promising associations between IBD and gene variants have been identified with the two best replicated so far being variants in the IL23R and ATG16L1 genes.
|
18341487 |
2008 |
|
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
SNPs rs1800896, rs3024505 (IL-10); rs11209026 (IL23R); rs2066844, rs2066845 (NOD-2), and rs2241880 (ATG16L1) were assessed in 93 patients with IBD and 200 healthy controls by hybridization probes and quantitative PCR.
|
31651650 |
2020 |