|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs (rs2241880 and rs6754677) in the ATG16L1 gene were significantly associated with the onset of CD in the Malaysian population.
|
31654602 |
2020 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One of those four patients was homozygous for the ATG16L1 Crohn's disease-associated gene variant but had no history of inflammatory bowel disease.
|
31692018 |
2020 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In patients, the CD-associated ATG16L1 T300A single-nucleotide polymorphism did not attenuate azathioprine induction of autophagy.
|
30889246 |
2019 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Interestingly, ATG16L1 has a single homolog, ATG16L2, which is independently implicated in diseases, including Crohn disease and systemic lupus erythematosus.
|
31451676 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATG16L1 polymorphisms have been linked to the development of Crohn's disease (CD), and phosphorylation of CD-associated ATG16L1 T300A (caATG16L1) has been hypothesized to contribute to cleavage and autophagy dysfunction.
|
31267703 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Antichitobioside was positive in 28% of patients with CD carrying the ATG16L1 A300T variant (either heterozygote or homozygote) compared with only 3% in those without the variant (P < 0.001).
|
30265311 |
2019 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118).
|
30818349 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.
|
29487628 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Gene-gene interaction analysis revealed significant interactions between MST1 and other susceptibility genes, including NOD2, MUC19 and ATG16L1 in contributing to Crohn's disease risk.
|
29441677 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study we studied the role of autophagy genes like IRGM (Immunity related GTPase M) and ATG16L1 (Autophagy related 16 like 1) in the pathogenesis of Crohn's Disease in Iranian patients.
|
29960072 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutations in the NOD2 (the intracellular sensor of bacteria) or ATG16L1 (autophagy protein) genes are susceptibility traits for Crohn's, and epithelia lacking either protein displayed enhanced IL-8 production in comparison to wild-type cells when exposed to DNP + E coli.
|
30030553 |
2018 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human macrophages with the Crohn's disease-associated Atg16l1 variant T300A exhibited more production of IFN-β and IL-1β.
|
29358708 |
2018 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Conclusion In this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease.
|
27698206 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities.
|
28466260 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, SHIP1 activity was shown to be correlated to the presence of a CD-associated single nucleotide polymorphism in ATG16L1.
|
28767696 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genetic risk factor associated specifically with Crohn's disease is a variant in ATG16L1 that reduces autophagy.
|
27435106 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD [10,049 with ulcerative colitis (UC) and 5595 with Crohn's disease (CD)] from 2011 to 2014.
|
28593437 |
2017 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study revealed that ATG16L1 deficiency led to alterations in macrophage function that contribute to the severity of CD.
|
28130498 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Impaired Paneth cell expression of antimicrobial protein (AMP) lysozyme is found in patients with Crohn's disease with the autophagy gene ATG16L1 risk allele, in mice with mutations in autophagy genes Atg16L1, Atg5 and Atg7, and in Irgm1 knockout mice.
|
28770667 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we report that mice with Atg16l1 deletion in intestinal epithelial cells (IECs) spontaneously develop transmural ileitis phenocopying ileal CD in an age-dependent manner, driven by the endoplasmic reticulum (ER) stress sensor IRE1α.
|
28082357 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD), 249 patients with ulcerative colitis (UC) and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform.
|
28542425 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer.
|
25645662 |
2016 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
ATG16L1 and LC3 expression was analyzed in the inflamed ileum and colon of 28 patients with Crohn's disease (CD), 14 with ulcerative colitis (UC) and 23 controls by western blot.
|
27335178 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |