Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ppp1r3a-knockout mice and wild-type littermates were subjected to in vivo programmed electrical stimulation to determine AF susceptibility.
|
31185731 |
2019 |
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We present a global gene interaction map of the human heart failure transition, identify previously unreported cardiac eQTLs, and demonstrate the discovery potential of disease-specific networks through the description of PPP1R3A as a central regulator in heart failure.
|
31235787 |
2019 |
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We present a global gene interaction map of the human heart failure transition, identify previously unreported cardiac eQTLs, and demonstrate the discovery potential of disease-specific networks through the description of PPP1R3A as a central regulator in heart failure.
|
31235787 |
2019 |
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of selected miRNAs (miR-199b-5p, miR-29c-3p, miR-204-5p, miR-125b-5p and miR-92a-3p) and genes (COL3A1, COL10A1, ERBB4, HMGA2, HLF, TOP2A, MMP3, MMP13, MMP10 and PPP1R3) were confirmed as altered in LSCC by RT-qPCR.
|
31109699 |
2019 |
Chronic atrial fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, PPP1R3A was progressively downregulated in the atria of patients with paroxysmal and persistent (chronic) AF.
|
31185731 |
2019 |
Language Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition to FOXP2, the patients' deletion involves two other genes, MDFIC and PPP1R3A, neither of which has been associated with speech or language disorders.
|
22106036 |
2012 |
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SSCP analysis of PPP1R3 showed abnormal patterns in 6 (12%) of the 50 colorectal cancers.
|
15870946 |
2005 |
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis.
|
15870946 |
2005 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
PPP1R3 gene alterations correlated with lymph node and liver metastases.
|
15870946 |
2005 |
Neoplasm Metastasis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We analyzed alterations in the PPP1R3 gene and its relationship to tumor progression and metastasis.
|
15870946 |
2005 |
Tumor Progression
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We analyzed alterations in the PPP1R3 gene and its relationship to tumor progression and metastasis.
|
15870946 |
2005 |
Disseminated Malignant Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Mindin/RG-1 protein expression is maintained in >80% of prostate cancers metastatic to bone or lymph nodes as well as in locally recurrent tumors in androgen-unresponsive patients.
|
16166318 |
2005 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mindin/RG-1 protein expression is maintained in >80% of prostate cancers metastatic to bone or lymph nodes as well as in locally recurrent tumors in androgen-unresponsive patients.
|
16166318 |
2005 |
Secondary malignant neoplasm of liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PPP1R3 gene alterations correlated with lymph node and liver metastases.
|
15870946 |
2005 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PPP1R3 gene (protein phosphatase 1) alterations in colorectal cancer and its relationship to metastasis.
|
15870946 |
2005 |
Polycystic Ovary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Studies of diabetic and nondiabetic PCOS women of other racial and ethnic backgrounds will be necessary to assess the impact of this and other variants in PPP1R3 upon the phenotype and natural history of women with PCOS.
|
15181086 |
2004 |
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The ARE insertion/deletion polymorphism of PPP1R3A has been associated with variation in glycaemic parameters and prevalence of diabetes.
|
12831406 |
2003 |
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The ARE insertion/deletion polymorphism of PPP1R3A has been associated with variation in glycaemic parameters and prevalence of diabetes.
|
12831406 |
2003 |
Alzheimer Disease, Late Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Additionally, in the dominant genetic model a marginally significant association in genotype frequencies between the Asp905Tyr PPP1R3 polymorphism and AD was observed (genotypes: OR 1.85, 95% CI 1.03 to 3.30, p = 0.04; alleles: OR 1.68, 95% CI 0.98 to 2.88, p = 0.06).
|
12185156 |
2002 |
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Recently, we found nonsense and missense mutations of the PPP1R3 (protein phosphatase 1, regulatory subunit 3) gene in diverse human cancer cell lines and primary lung carcinomas, indicating that PPP1R3 functions as a tumor suppressor in human carcinogenesis.
|
10698503 |
2000 |
Myeloid Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that PPP1R3 is not a major target of 7q deletions in myeloid leukemia, however, alterations of the PPP1R3 gene may contribute to the development of a subset of hematological malignancies.
|
10995882 |
2000 |
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To evaluate the possible involvement of the PPP1R3 gene in the development of hematological malignancies, we examined 72 leukemia and lymphoma cell lines for alterations of the PPP1R3 gene by PCR-SSCP and direct sequence analyses.
|
10995882 |
2000 |
Impaired glucose tolerance
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this study was to investigate whether two common variants in the PPP1R3 gene, Asp905Tyr and PP1ARE, are associated with reduced insulin sensitivity or can predict the development of impaired glucose tolerance (IGT) or type 2 diabetes during a 20-year follow-up period in 696 50-year-old Caucasian men.
|
10868947 |
2000 |
Hematologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results indicate that PPP1R3 is not a major target of 7q deletions in myeloid leukemia, however, alterations of the PPP1R3 gene may contribute to the development of a subset of hematological malignancies.
|
10995882 |
2000 |
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the possible involvement of the PPP1R3 gene in the development of hematological malignancies, we examined 72 leukemia and lymphoma cell lines for alterations of the PPP1R3 gene by PCR-SSCP and direct sequence analyses.
|
10995882 |
2000 |