|
Global developmental delay
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
We now report 16 individuals with mild to profound ID and DD and a de novo mutation in PPP2CA, encoding the catalytic Cα subunit.
|
30595372 |
2019 |
|
Intellectual Disability
|
0.310 |
GeneticVariation
|
group |
BEFREE |
We now report 16 individuals with mild to profound ID and DD and a de novo mutation in PPP2CA, encoding the catalytic Cα subunit.
|
30595372 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Furthermore, in human breast cancer samples, PP2Ac expression is negatively correlated with the phosphorylation of Girdin, and low expression of PP2Ac is correlated with tumor stage, grade and lymph node metastasis of breast cancer.
|
30935690 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We have previously shown that alterations in Arl2 protein content were associated with corresponding modifications of the tumor suppressor PP2Ac protein content in breast cancer cells.
|
18818514 |
2008 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the downregulated expression of PPP2CA was significantly correlated with tumor stage and Gleason grade.
|
17977648 |
2008 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Metformin treatment also significantly reduced tumor formation in vivo as well as protein expression of PCNA, Akt, Myc, and serine phosphorylation of the latter 2, which can be partially blocked by O/E α4 or sh-PP2Ac.
|
30693913 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Association between PPP2CA expression and colorectal cancer prognosis tumor marker prognostic study.
|
30296597 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model.
|
24642616 |
2014 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
DBTC promoted xenograft growth and metastasis, induced tumor-associated macrophage infiltration, promoted angiogenesis, activated the nuclear factor-κB (NF-κB) pathway, and repressed PP2Ac expression.
|
26761431 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the minor allele of PPP2CA rs10491322 as a risk factor was correlated with immunologic disorders for SLE.
|
29979448 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
We propose the use of PP2Ac-siRNA as a novel tool to correct T cell IL-2 production in SLE patients.
|
16224536 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
We propose that enhanced PP2Ac in SLE T-cells may dephosphorylate and activate the signaling pathway upstream of DNMT1, thus disturbing the tight control of methylation-sensitive genes, which are involved in SLE pathogenesis.
|
23775084 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A 32-kb haplotype comprising multiple SNPs of PPP2CA showed significant association with SLE in Hispanic Americans, European Americans, and Asians, but not in African Americans.
|
21590681 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of TCF7 and PPP2CA messenger RNA in patients with SLE were significantly decreased compared with those in healthy controls.
|
28144936 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We conclude that increased PP2Ac expression participates in SLE pathogenesis by promoting inflammation through unchecked IL-17 production and facilitating the development of end-organ damage.
|
22422882 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The latter notion implies that PP2Calpha may possess tumor-suppressing properties, and it thereby sets the stage for more elaborate analyses on its involvement in the development and progression of cancer.
|
17941990 |
2007 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders.
|
30186749 |
2018 |
|
Malignant Neoplasms
|
0.030 |
PosttranslationalModification
|
group |
BEFREE |
Therefore, disruption of PP2Ac methylation may contribute to cancer, and modulation of this methylation may serve as an anticancer target.
|
22904676 |
2012 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Animal studies revealed a suppressive effect of PPP2CA expression on PCa growth and metastasis.
|
24642616 |
2014 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
High PP2Ac expression was significantly (P < 0.01) associated with serum hepatitis B surface antigen positivity, serum hepatitis B e antigen positivity, liver cirrhosis, moderate to poor differentiation grade, advanced disease stage, intrahepatic metastasis, and early recurrence in HCC.
|
26618405 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
DBTC promoted xenograft growth and metastasis, induced tumor-associated macrophage infiltration, promoted angiogenesis, activated the nuclear factor-κB (NF-κB) pathway, and repressed PP2Ac expression.
|
26761431 |
2016 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Animal studies revealed a suppressive effect of PPP2CA expression on PCa growth and metastasis.
|
24642616 |
2014 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our data show that the PPP2CA expression and PP2A activity is downregulated in androgen-independent (C4-2) prostate cancer cells as compared with androgen-dependent (LNCaP) cells.
|
21393425 |
2011 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
Further investigation of one of the genes, PPP2CA, which encodes the catalytic subunit of a serine phosphatase PP2A, a potent tumor suppressor, revealed that its expression was decreased in prostate cancer compared to adjacent normal/benign tissue.
|
17977648 |
2008 |
|
Prostate carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our data show that the PPP2CA expression and PP2A activity is downregulated in androgen-independent (C4-2) prostate cancer cells as compared with androgen-dependent (LNCaP) cells.
|
21393425 |
2011 |