|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we observed significant levels of SNO-Cdk5 in postmortem Alzheimer's disease (AD) but not in normal human brains.
|
21844361 |
2011 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We recently reported in Alzheimer's disease (AD) that S-nitrosylation of Drp1 (forming S-nitroso [SNO]-Drp1) results in GTPase hyperactivity and mitochondrial fragmentation, thus impairing bioenergetics and inducing synaptic damage and neuronal loss.
|
23641925 |
2013 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Despite some studies into the role of SNO in AD, multiple identified SNO proteins lack deep investigation and SNO modifications outside of brain tissues are limited, leaving the full role of SNO in AD to be elucidated.
|
31606089 |
2019 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, we detect SNO-PTEN in human brains with sporadic PD.
|
25378175 |
2014 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We observed increased SNO-Prx2 in human Parkinson's disease (PD) brains, and S-nitrosylation of Prx2 inhibited both its enzymatic activity and protective function from oxidative stress.
|
18003920 |
2007 |
|
Parkinson Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We first showed that SNO-Parkin reduced its ability as a suppressor of Drp1 expression, leading to upregulation of Drp1 in neurotoxin-based PD models, in vitro and in vivo.
|
27267045 |
2016 |
|
Malignant neoplasm of esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
We investigated the antiproliferative effects of AuNP synthesized from MO aqueous leaf extracts (MLAuNP ) in A549 lung and SNO oesophageal cancer cells.
|
26923760 |
2016 |
|
Malignant neoplasm of esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
This study investigated FA-induced cytotoxicity and apoptotic induction in the SNO OC cell line.
|
27956242 |
2017 |
|
Malignant neoplasm of esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
A Comparison of the Toxicity of Mono, Bis, Tris and Tetrakis Phosphino Silver Complexes on SNO Esophageal Cancer Cells.
|
28530542 |
2018 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Anticonvulsant prophylaxis and steroid use in adults with metastatic brain tumors: summary of SNO and ASCO endorsement of the Congress of Neurological Surgeons guidelines.
|
30883663 |
2019 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Site-specific subgroup analysis further showed that copy number gains of CCNL1 and SNO occurred more frequently in oral carcinomas in advanced clinical stages as compared to N0 oral lesions (CCNL1: P=0.03; SNO: P=0.03).
|
15700036 |
2005 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Copy numbers of EVI1 and TERC increased more than those of SNO and PIK3CA in our panel of NSCLC cell lines.
|
14581340 |
2003 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.
|
11511096 |
2001 |
|
Dyskinetic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The "NR2B/NMDAR-nNOS/NO-SNO-Src-p-Src-NR2B/NMDAR" signaling cycle may be the molecular basis of NR2B tyrosine phosphorylation upward positive feedback, which demonstrates the possibility as one latent target for dyskinesia therapy.
|
30350722 |
2019 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A Comparison of the Toxicity of Mono, Bis, Tris and Tetrakis Phosphino Silver Complexes on SNO Esophageal Cancer Cells.
|
28530542 |
2018 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNO-Drp1 is a key mediator of mutHTT toxicity, and, thus, may represent a novel drug target for HD.
|
23641925 |
2013 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
To discuss the role of survivorship care and survivorship care plans, including a recently developed neuro-oncology-specific plan care (https://www.soc-neuro-onc.org/SNO/Resources/Survivorship_Care_Plan.aspx) for adult patients diagnosed with primary glial neoplasms and the necessary educational needs of oncology nurses.
|
30446382 |
2018 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we found that S-nitrosylation of O-linked N-acetylglucosaminyltransferase (SNO-OGT) was induced by β-amyloid peptide (Aβ) exposure to SK-N-MC and SK-N-SH human neuroblastoma cells.
|
26854602 |
2016 |
|
Pneumococcal Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Genetic ablation of the clock gene Bmal1 (also called Arntl or MOP3) in bronchiolar cells disrupts rhythmic Cxcl5 expression, resulting in exaggerated inflammatory responses to lipopolysaccharide and an impaired host response to Streptococcus pneumoniae infection.
|
25064128 |
2014 |
|
Chagas Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The multivariate adaptive regression splines (MARS) modeling, comparing differences in relative SNO level (Asc<sup>-</sup>/Asc+ ratio) of the protein spots between any two groups yielded SNO biomarkers that exhibited ≥90% prediction success in classifying ChD CA (582-KRT1 and 884-TPM3) and ChD CS (426-PNP, 582-KRT1, 486-ALB, 662-ACTB) patients from NH controls.
|
30697201 |
2018 |
|
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Comparison of the Toxicity of Mono, Bis, Tris and Tetrakis Phosphino Silver Complexes on SNO Esophageal Cancer Cells.
|
28530542 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders.
|
29097102 |
2017 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we found that S-nitrosylation of O-linked N-acetylglucosaminyltransferase (SNO-OGT) was induced by β-amyloid peptide (Aβ) exposure to SK-N-MC and SK-N-SH human neuroblastoma cells.
|
26854602 |
2016 |
|
Glucocorticoid-remediable aldosteronism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Kinetic analyses suggested an AKR1A1 substrate preference of SNO-CoA > GSNO.
|
31649033 |
2019 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
SNO-proteins in two ASD-related brain regions, cortex and striatum of young and adult InsG3680(+/+) mice (a human mutation-based Shank3 mouse model), were identified by an innovative mass spectrometric method, SNOTRAP.
|
29988084 |
2018 |