|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Protein phosphatase 2A (PP2A), in its activated form as a phosphatase, is a tumour suppressor.
|
20558158 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The serine/threonine Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating multiple oncogenic signaling pathways.
|
31541192 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Data from murine models exhibited a marked reduction in the tumor size, increased apoptosis, inhibited NF-κB, S1PR1/STAT3, Shh signaling and desmoplasia, modulated the expression of gemcitabine-metabolizing transport enzymes, and restored the expression of tumor suppressor gene PP2A.
|
30083262 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Given the tumor suppressor activities of PP2A, here we evaluate whether this genetic variant associates with the age of diagnosis and recurrence of breast cancer in women.
|
20669227 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
|
28174209 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The PPP2R1B gene, which encodes the beta isoform of the A subunit of the serine/threonine protein phosphatase 2A (PP2A), was identified as a putative human tumor suppressor gene.
|
9765152 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased expression of p-PP2A in the tumor tissues was significantly correlated with higher N2/N3-stage (aOR = 2.1, 95%CI: 1.2-3.8).
|
28516459 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, we show that tumor suppressor gene BRCA1 and PP2A are inhibited by these NO levels.
|
28162269 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also found that miR-183 directly targeted tumor suppressor, specifically the 3'UTR of three subunits of protein phosphatase 2A (PP2A-Cα, PP2A-Cβ, and PP2A-B56-γ) transcripts, inhibiting their expression and regulated the downstream regulators p21, p27, MMP2/3/7 and TIMP1/2/3/4.
|
25152390 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancerous inhibitor of protein phosphatase 2A (CIP2A) an endogenous inhibitor of protein phosphatase 2A (PP2A), which can promote proliferation and transformation of several cancer types, has been shown to be a target for tumor therapy.
|
29568959 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine phosphatases and functions as a tumor suppressor that negatively regulates the activity of some oncogenic kinases.
|
24204789 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our strategy of reactivating endogenous PP2A may be applicable to the treatment of other diseases and represents an advancement toward the development of small molecule activators of tumor suppressor proteins.
|
28504649 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein phosphatase 2A (PP2A) is a tumor suppressor whose function is lost in many cancers.
|
25939762 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition to AKT and ERK activation, SPRY2 loss also activates a PP2A-dependent tumor suppressor checkpoint.
|
23434594 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results, which uncover a role of the eEF-2K-mediated control of PP2A-A in tumor cell glycolysis, provide new insights into the regulation of the Warburg effect.
|
27181208 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Many groups have explored the therapeutic venue of combining PP2A reactivation with kinase inhibition to counteract the very changes in tumor suppressors and oncogenes that lead to cancer development.
|
30401535 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review will summarize literature that implicates PP2A as a tumor suppressor, explore PP2A mutations identified in human malignancy, and focus on PP2A in the regulation of Wnt signaling and stem cells so as to better understand how aberrancy in this pathway can contribute to tumorigenesis.
|
29495399 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SET could promote the occurrence of tumor through inhibiting PP2A.
|
25234598 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As PP2A is widely regarded as a tumor suppressor, we resorted to gene expression datasets from cancer patients to functionally dissect its therapeutic relevance.
|
27557495 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein phosphatase 2A (PP2A) is a well-known tumor suppressor frequently inhibited in human cancer.
|
26234767 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PR55α-PP2A specifically dephosphorylates T239 of c-Jun, promoting its binding to genes regulating tumour cell migration and invasion.
|
24632621 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase.
|
30555827 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein phosphatase 2A (PP2A) is a tumor suppressor that regulates many signaling pathways crucial for cell transformation.
|
24448818 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Polyomavirus middle (PyMT) and small (PyST) tumor antigens and SV40 small tumor antigen (SVST) are oncoproteins that block PP2A function by replacing certain B-type subunits, resulting in cellular transformation.
|
22904676 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein phosphatase 2A (PP2A) is a tumor suppressor that negatively regulates the same cancer-related signaling pathways that are activated by NO.
|
21893353 |
2011 |