AVPR1B, arginine vasopressin receptor 1B, 553

N. diseases: 29; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.210 Therapeutic disease RGD Vasopressin V1B receptor antagonists may be effective for the treatment of depression and anxiety and the objective of this study was to characterize the pharmacological profiles of two newly synthesized arginine vasopressin receptor 1B (V1B receptor) antagonists, TASP0233278 and TASP0390325. 24654684 2014
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.220 Therapeutic group RGD Vasopressin V1B receptor antagonists may be effective for the treatment of depression and anxiety and the objective of this study was to characterize the pharmacological profiles of two newly synthesized arginine vasopressin receptor 1B (V1B receptor) antagonists, TASP0233278 and TASP0390325. 24654684 2014
CUI: C0221406
Disease: Pituitary-dependent Cushing's disease
Pituitary-dependent Cushing's disease 		0.020 Biomarker disease BEFREE All evaluated proteins [USP8, arginine vasopressin receptor 1b and 2, corticotropin-releasing hormone receptor, cAMP response element-binding protein (CREB), p27/kip1, cyclin E, heat shock protein 90 (HSP90), orphan nuclear receptor 4, epidermal growth factor receptor, histone deacetylase 2, glucocorticoid receptor, cyclin-dependent kinase 5 and Abelson murine leukemia viral oncogene homolog 1 enzyme substrate 1] were known to be deregulated in CD. 30844069 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. 22341483 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. 22341483 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.210 GeneticVariation disease BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 GeneticVariation disease BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 GeneticVariation phenotype BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.220 GeneticVariation group BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 GeneticVariation disease BEFREE By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. 23422793 2013
CUI: C0221406
Disease: Pituitary-dependent Cushing's disease
Pituitary-dependent Cushing's disease 		0.020 AlteredExpression disease BEFREE CRHR, V1bR, and 11beta-HSD2 mRNA levels in CD were greater than those in SCA and NFT. 18057378 2007
CUI: C0018790
Disease: Cardiac Arrest
Cardiac Arrest 		0.010 AlteredExpression disease BEFREE CRHR, V1bR, and 11beta-HSD2 mRNA levels in CD were greater than those in SCA and NFT. 18057378 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.010 GeneticVariation disease BEFREE Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder. 23962971 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.200 Biomarker disease RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0236664
Disease: Alcohol-Related Disorders
Alcohol-Related Disorders 		0.200 Biomarker group RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0236970
Disease: Alcohol-Induced Disorders
Alcohol-Induced Disorders 		0.200 Biomarker group RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C2751719
Disease: ALCOHOL DEPENDENCE, PROTECTION AGAINST
ALCOHOL DEPENDENCE, PROTECTION AGAINST 		0.200 Biomarker phenotype RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C3887915
Disease: AERODIGESTIVE TRACT CANCER, SQUAMOUS CELL, ALCOHOL-RELATED, PROTECTION AGAINST
AERODIGESTIVE TRACT CANCER, SQUAMOUS CELL, ALCOHOL-RELATED, PROTECTION AGAINST 		0.200 Biomarker phenotype RGD Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. 21309953 2012
CUI: C0154409
Disease: Recurrent major depressive episodes
Recurrent major depressive episodes 		0.010 GeneticVariation disease BEFREE Five SNPs were identified in AVPR1b and genotyped in two well-diagnosed samples of patients with recurrent major depression and matched controls. 15094789 2004
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.010 GeneticVariation group BEFREE Four tag single nucleotide polymorphisms (SNPs: rs35810727, rs28373064, rs35439639, rs35608965) of AVPR1B were genotyped in the cardiovascular cohort (n=6103) of MDC (MDC-CC) and associated with measures of obesity and DM. 26503846 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation disease BEFREE Four tag single nucleotide polymorphisms (SNPs: rs35810727, rs28373064, rs35439639, rs35608965) of AVPR1B were genotyped in the cardiovascular cohort (n=6103) of MDC (MDC-CC) and associated with measures of obesity and DM. 26503846 2016
CUI: C0001231
Disease: ACTH Syndrome, Ectopic
ACTH Syndrome, Ectopic 		0.010 AlteredExpression disease BEFREE Higher expression of AVPR1B was observed in the EAS patients responsive to desmopressin, as well as in corticotrophic tumors, as compared with normal pituitary samples, but no correlation between AVPR1B expression and response to desmopressin was observed in the CD patients. 18426818 2008
CUI: C0025193
Disease: Melancholia
Melancholia 		0.010 GeneticVariation disease BEFREE No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder. 23068076 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 Biomarker group PSYGENET Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. 24012103 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder. 24012103 2013