Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of PP4C in PDAC samples was associated with higher frequencies of distant metastasis (P = 0.02) and poor disease-free and overall survivals in patients with stage II PDAC (P = 0.006 and 0.02) independent of tumor size, margin status, and lymph node status (stage).
|
22665577 |
2012 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The median Ki-67, MC, and PPH3 in metastases were statistically higher than in PT (p = 0.0002, 0.02, and 0.01).
|
27048356 |
2016 |
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Multivariate analysis of all features with distant metastases free survival as the end-point showed that the combination of MARCKSL1 protein and phosphohistone H3 (PPH3) has the strongest independent prognostic value.
|
22772381 |
2012 |
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Supervised hierarchical cluster analysis for distant-metastasis-free survival in the subgroup of patients with strong PPH3 expression revealed that the genes involved in Notch signalling and cell adhesion were expressed at higher levels in those patients with distant metastasis.
|
24599057 |
2014 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Ki-67 expression correlated with angiolymphatic invasion (P=0.01) but not with tumor size or lymph node metastasis; PPH3 expression showed no association with any of these 3 parameters.
|
21297447 |
2011 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.
|
31272138 |
2019 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Overexpression of PP4C in PDAC samples was associated with higher frequencies of distant metastasis (P = 0.02) and poor disease-free and overall survivals in patients with stage II PDAC (P = 0.006 and 0.02) independent of tumor size, margin status, and lymph node status (stage).
|
22665577 |
2012 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Tumor grade was evaluated for PT and LM according to the WHO classification, using Ki-67 labeling and mitotic count (MC) evaluated with or without phospho-histone H3 (PPH3).
|
27048356 |
2016 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing the expression of PP4C resulted in the inhibition of cell proliferation and invasion.
|
25927939 |
2015 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Ki-67 expression correlated with angiolymphatic invasion (P=0.01) but not with tumor size or lymph node metastasis; PPH3 expression showed no association with any of these 3 parameters.
|
21297447 |
2011 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The lack of ppx genes resulted in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of poly-P is critical for ppx genes in C. jejuni pathophysiology.
|
24569519 |
2014 |
Pancreatic Ductal Adenocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We examined the expression of PP4 catalytic subunit (PP4C) protein in 133 patients with stage II pancreatic ductal adenocarcinoma (PDAC) and their paired benign pancreatic samples (N = 113) by immunohistochemistry.
|
22665577 |
2012 |
Pancreatic Ductal Adenocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests an important role of protein phosphatase 4 (PP4C) in the progression of several cancers, including breast cancer, lung cancer and pancreatic ductal adenocarcinoma.
|
25927939 |
2015 |
Secondary Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Multivariate analysis of all features with distant metastases free survival as the end-point showed that the combination of MARCKSL1 protein and phosphohistone H3 (PPH3) has the strongest independent prognostic value.
|
22772381 |
2012 |
Secondary Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The median Ki-67, MC, and PPH3 in metastases were statistically higher than in PT (p = 0.0002, 0.02, and 0.01).
|
27048356 |
2016 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests an important role of protein phosphatase 4 (PP4C) in the progression of several cancers, including breast cancer, lung cancer and pancreatic ductal adenocarcinoma.
|
25927939 |
2015 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The ectopic expression of PP4C promoted CRC cell proliferation, migration and invasion in vitro and tumor growth and lung metastasis in vivo.
|
25927939 |
2015 |
Dyskinetic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results showed that PPX patch treatment improved dyskinesia.
|
30241783 |
2018 |
Hemorrhoids
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Between 2011 and 2015, stapled anopexy was performed for hemorrhoids and/or anal prolapse in 141 patients (n = 25 conventional PPH-3©-stapler versus n = 116 high-volume CHEX©-stapler).
|
29131098 |
2018 |
Fibroid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied cell proliferation with 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide, and, mitotic activity with phosphohistone H3 (PPH3) expression in leiomyoma, and, matched, normal, smooth muscle tissues using standard immunohistochemistry.
|
26416628 |
2015 |
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we evaluated the neuroprotective effects and underlying mechanisms of pramipexole patch (PPX patch) in a subacute PD mouse model induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
|
30241783 |
2018 |
Uterine Fibroids
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We studied cell proliferation with 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide, and, mitotic activity with phosphohistone H3 (PPH3) expression in leiomyoma, and, matched, normal, smooth muscle tissues using standard immunohistochemistry.
|
26416628 |
2015 |
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The ectopic expression of PP4C promoted CRC cell proliferation, migration and invasion in vitro and tumor growth and lung metastasis in vivo.
|
25927939 |
2015 |
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our data suggested a potential role of PP4C in tumor progression and provided novel insights into the mechanism of how this factor positively regulated cell proliferation and invasion in CRC cells.
|
25927939 |
2015 |
Endometrial Stromal Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPH3 and Ki67 counts can be easier to perform than MAI and therefore helpful in the diagnosis of ESS, Low Grade.
|
24146786 |
2013 |