|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RNA binding protein immunoprecipitation (RIP) assays demonstrated that metastasis associated lung adenocarcinoma transcript 1 (MALAT1), SOX2 overlapping transcript (SOX2OT) and maternally expressed 3 (MEG3) among the 8 candidates bound to the NSPc1 protein complex in glioma H4 cells.
|
30720120 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, the present data provided novel insight into the roles of MEG3 in glioma, and MEG3/miR‑96‑5p/MTSS1 signaling could be a promising therapeutic target for the treatment of patients with glioma.
|
31545491 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Participation of tumor suppressors long non-coding RNA MEG3, microRNA-377 and PTEN in glioma cell invasion and migration.
|
31378455 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of MEG3 in glioma remains unclear.
|
30417553 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MTT assay, flow cytometry, and immunofluorescence assay were carried out to detect the impact of MEG3 on glioma cell proliferation, apoptosis, and autophagy.
|
30284203 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the findings in the present study indicated that TUN treatment inhibited growth and aggressiveness through MEG-3-mediated wnt/β-catenin signaling, suggesting that TUN may be an efficient anticancer agent for the treatment of glioma.
|
29805584 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Downregulated expression of MEG3 was also detected in two human glioma cell lines (U-251, M059J) compared with normal astrocyte cells.
|
28791407 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings revealed that downregulated lncRNA MEG3 could promote glioma cell proliferation through targeting Wnt/β-catenin signaling, which mainly influenced cell cycle.
|
29027534 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study is the first to demonstrate that lncRNA MEG3 suppresses glioma cell proliferation, migration, and invasion by acting as a ceRNA of miR-19a, which provides a novel insight about the pathogenesis of glioma.
|
28276316 |
2017 |
|
Glioma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Treatment of glioma cells with the DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-AzadC) decreased aberrant hypermethylation of the MEG3 promoter and prevented the loss of MEG3 expression.
|
26676363 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest an important role of MEG3 in the molecular etiology of glioma and implicate the potential application of MEG3 in glioma therapy.
|
22234798 |
2012 |