|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The long noncoding RNA MEG3 is a significant tumor-suppressive gene in various tumors.
|
31294463 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, MEG3 inhibited tumour growth and up-regulated expression of QKI-5 in vivo.
|
30565858 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results indicated that MEG3 levels were positively correlated with GH and IGF-1 levels, and negatively correlated with the tumor volume of GH-secreting tumors.
|
30867789 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a classical long noncoding RNA (lncRNA), maternally expressed gene 3 (MEG3) has been reported to exhibit pivotal regulatory roles in the occurrence and development of various digestive system tumors.
|
31119760 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-377 mimics and MEG3 were tumor suppressors in glioma cells through regulating PTEN expression.
|
31378455 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA-211.
|
31124134 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been implicated as a tumor suppressor gene in several human cancer types.
|
30556250 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Likewise, the long noncoding RNA maternally expressed gene 3 (MEG3) is a tumor suppressor that has been shown to regulate cancer cell apoptosis and migration; however, its role in VSMC loss is unclear.
|
31099432 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC).
|
31531526 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo experiment demonstrated that overexpression of MEG3 inhibited tumor growth in breast cancer by suppressing miR-21.
|
30389444 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we found that MEG3 expression was significantly downregulated in tumour tissues, and its low expression was associated with large tumour size, lymph node metastasis and advanced clinical stage in ESCC patients.
|
30990378 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To conclude, as our findings proved, MEG3 is likely to act as a tumor suppressor in the pathogenesis of CRC by means of the regulation of the miR-376/PRDK1 signal axis, suggesting that MEG3 has the potential to become a novel therapeutic target for the treatment of CRC.
|
31632544 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo tumor formation experiments showed that MEG3 inhibited the tumor formation ability of cervical cancer cells.
|
31320837 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present review highlights biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs.
|
30793226 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long non-coding RNA (lncRNA) MEG3, an identified tumor suppressor, has been implicated in the development of various cancers.
|
31488093 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Once the expression of MEG3 is restored or methylation is inhibited, tumor growth can be inhibited both <i>in vivo</i> and <i>in vitro</i>.
|
31584879 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The long noncoding RNA maternally expressed gene 3 (MEG3) is an imprinted gene, which participates in various cancers as a tumor suppressor.
|
30644097 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA.
|
31326791 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Meg3 has been shown to play an important role in the regulation of cellular proliferation and functions as a tumor suppressor in numerous tissues.
|
30765776 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages.
|
31413531 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study also revealed that lncRNA‑MEG3 transfection suppressed tumor growth mainly by decreasing the expression of vascular endothelial growth factor and increasing the expression of Bcl‑2 in vivo.
|
31524253 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long non-coding RNA (LncRNA) MEG3 has been demonstrated as a tumor suppressor in various cancers, including thyroid carcinoma (TC).
|
30021359 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA maternally expressed gene 3 (MEG3) is a tumor suppressor in diverse cancer types.
|
30417553 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MTT, colony formation assay, flow cytometry analysis and a subcutaneous xenograft tumor model were conducted to assess the effects of MEG3 on the HAs tumorigenesis.
|
30562741 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, long non-coding RNA (lncRNA) MEG3, an identified tumor suppressor, was explored for its role in the chemotherapy of lung cancer.
|
29509250 |
2018 |